背侧海马中的谷氨酸受体介导急性吗啡戒断引起的条件性位置厌恶的获得，但不介导其表达。
Glutamate receptors in the dorsal hippocampus mediate the acquisition, but not the expression, of conditioned place aversion induced by acute morphine withdrawal in rats.
机构信息
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
出版信息
Acta Pharmacol Sin. 2009 Oct;30(10):1385-91. doi: 10.1038/aps.2009.130. Epub 2009 Sep 21.
Abstract
AIM
To evaluate the role of glutamate receptors in the dorsal hippocampus (DH) in the motivational component of morphine withdrawal.
METHODS
NMDA receptor antagonist D-AP5 (5 microg/0.5 microL per side) or AMPA receptor antagonist NBQX (2 microg/0.5 microL per side) was microinjected into DH of rats. Conditioned place aversion (CPA) induced by naloxone-precipitated morphine withdrawal were assessed.
RESULTS
Preconditioning microinjection of D-AP5 or NBQX into the DH impaired the acquisition of CPA in acute morphine-dependent rats. However, intra-DH microinjection of D-AP5 or NBQX after conditioning but before the testing session had no effect on the expression of CPA.
CONCLUSION
Our results suggest that NMDA and AMPA receptors in the dorsal hippocampus are involved in the acquisition, but not in the expression, of the negative motivational components of acute morphine withdrawal in rats.
摘要
目的
评估背侧海马（DH）中的谷氨酸受体在吗啡戒断的动机成分中的作用。
方法
将 NMDA 受体拮抗剂 D-AP5（每侧 5μg/0.5μL）或 AMPA 受体拮抗剂 NBQX（每侧 2μg/0.5μL）微注射到大鼠的 DH 中。评估纳洛酮诱发的吗啡戒断引起的条件性位置厌恶（CPA）。
结果
在急性吗啡依赖大鼠中，预先将 D-AP5 或 NBQX 微注射到 DH 中会损害 CPA 的获得。然而，在条件作用后但在测试阶段之前将 D-AP5 或 NBQX 微注射到 DH 中对 CPA 的表达没有影响。
结论
我们的结果表明，背侧海马中的 NMDA 和 AMPA 受体参与了大鼠急性吗啡戒断的负性动机成分的获得，但不参与其表达。
相似文献
1
Glutamate receptors in the dorsal hippocampus mediate the acquisition, but not the expression, of conditioned place aversion induced by acute morphine withdrawal in rats.背侧海马中的谷氨酸受体介导急性吗啡戒断引起的条件性位置厌恶的获得，但不介导其表达。
Acta Pharmacol Sin. 2009 Oct;30(10):1385-91. doi: 10.1038/aps.2009.130. Epub 2009 Sep 21.
2
Involvement of glutamate receptors within the central nucleus of the amygdala in naloxone-precipitated morphine withdrawal-induced conditioned place aversion in rats.杏仁核中央核内谷氨酸受体参与大鼠纳洛酮诱发的吗啡戒断所致条件性位置厌恶。
Jpn J Pharmacol. 2002 Apr;88(4):399-406. doi: 10.1254/jjp.88.399.
3
Dorsal hippocampal NMDA receptor blockade impairs extinction of naloxone-precipitated conditioned place aversion in acute morphine-treated rats by suppressing ERK and CREB phosphorylation in the basolateral amygdala.背侧海马N-甲基-D-天冬氨酸受体阻断通过抑制基底外侧杏仁核中的细胞外信号调节激酶（ERK）和环磷腺苷效应元件结合蛋白（CREB）磷酸化，损害急性吗啡处理大鼠中纳洛酮诱发的条件性位置厌恶的消退。
Br J Pharmacol. 2015 Jan;172(2):482-91. doi: 10.1111/bph.12671. Epub 2014 Jul 1.
4
Effect of glutamate receptor antagonists microinjected into the nucleus accumbens on place aversion induced by naloxone in single-dose, morphine-treated rats.阿肯伯氏核内注射谷氨酸受体拮抗剂对单次剂量吗啡处理大鼠纳洛酮诱导的位置厌恶的影响。
Eur J Pharmacol. 2011 Sep;666(1-3):131-4. doi: 10.1016/j.ejphar.2011.05.022. Epub 2011 May 27.
5
α7 Nicotinic acetylcholine receptors in the central amygdaloid nucleus alter naloxone-induced withdrawal following a single exposure to morphine.中脑杏仁核核内的α7 型烟碱型乙酰胆碱受体改变单次吗啡暴露后纳洛酮诱导的戒断反应。
Psychopharmacology (Berl). 2011 Apr;214(4):923-31. doi: 10.1007/s00213-010-2101-7. Epub 2010 Dec 2.
6
Effects of exogenous cholecystokinin octapeptide on acquisition of naloxone precipitated withdrawal induced conditioned place aversion in rats.外源性胆囊收缩素八肽对纳洛酮诱发的条件性位置厌恶大鼠获得的影响。
PLoS One. 2012;7(7):e41860. doi: 10.1371/journal.pone.0041860. Epub 2012 Jul 27.
7
Distinctive roles of L-type calcium channels subtypes within the dorsal hippocampus in formation of morphine withdrawal-induced aversion in rats.L 型钙通道亚型在大鼠背海马中的独特作用在吗啡戒断诱导厌恶反应中的形成。
Prog Neuropsychopharmacol Biol Psychiatry. 2023 Dec 20;127:110818. doi: 10.1016/j.pnpbp.2023.110818. Epub 2023 Jun 20.
8
The small GTPase RhoA, but not Rac1, is essential for conditioned aversive memory formation through regulation of actin rearrangements in rat dorsal hippocampus.小分子 GTP 酶 RhoA，但不是 Rac1，通过调节大鼠背侧海马中的肌动蛋白重排，对于条件性厌恶记忆的形成是必不可少的。
Acta Pharmacol Sin. 2013 Jun;34(6):811-8. doi: 10.1038/aps.2013.3. Epub 2013 Apr 8.
9
Involvement of actin rearrangements within the amygdala and the dorsal hippocampus in aversive memories of drug withdrawal in acute morphine-dependent rats.杏仁核和背侧海马体中肌动蛋白重排参与急性吗啡依赖大鼠戒断药物的厌恶记忆形成。
J Neurosci. 2009 Sep 30;29(39):12244-54. doi: 10.1523/JNEUROSCI.1970-09.2009.
10
Involvement of noradrenergic system within the central nucleus of the amygdala in naloxone-precipitated morphine withdrawal-induced conditioned place aversion in rats.大鼠中杏仁核中央核内去甲肾上腺素能系统参与纳洛酮诱发的吗啡戒断所致条件性位置厌恶
Psychopharmacology (Berl). 2003 Oct;170(1):80-8. doi: 10.1007/s00213-003-1504-0. Epub 2003 May 27.
引用本文的文献
1
Alterations of Dopamine Receptors and the Adaptive Changes of L-Type Calcium Channel Subtypes Regulate Cocaine-Seeking Habit in Tree Shrew.多巴胺受体的改变及L型钙通道亚型的适应性变化调节树鼩的觅可卡因习惯。
Life (Basel). 2022 Jun 30;12(7):984. doi: 10.3390/life12070984.
2
Sex and chronic stress alter the distribution of glutamate receptors within rat hippocampal CA3 pyramidal cells following oxycodone conditioned place preference.在羟考酮条件性位置偏爱后，性别和慢性应激会改变大鼠海马CA3锥体细胞内谷氨酸受体的分布。
Neurobiol Stress. 2022 Jan 29;17:100431. doi: 10.1016/j.ynstr.2022.100431. eCollection 2022 Mar.
3
Glutamatergic Systems and Memory Mechanisms Underlying Opioid Addiction.阿片类药物成瘾的谷氨酸能系统和记忆机制。
Cold Spring Harb Perspect Med. 2021 Mar 1;11(3):a039602. doi: 10.1101/cshperspect.a039602.
4
Anterior cingulate cortex and dorsal hippocampal glutamate receptors mediate generalized fear in female rats.前扣带皮层和背侧海马谷氨酸受体介导雌性大鼠的普遍恐惧。
Psychoneuroendocrinology. 2019 Sep;107:109-118. doi: 10.1016/j.psyneuen.2019.05.009. Epub 2019 May 10.
5
Formation of aversive memories associated with conditioned drug withdrawal requires BDNF expression in the amygdala in acute morphine-dependent rats.在急性吗啡依赖大鼠中，与条件性药物戒断相关的厌恶记忆形成需要杏仁核中脑源性神经营养因子（BDNF）的表达。
Acta Pharmacol Sin. 2015 Dec;36(12):1437-43. doi: 10.1038/aps.2015.94. Epub 2015 Nov 16.
6
Dorsal hippocampal NMDA receptor blockade impairs extinction of naloxone-precipitated conditioned place aversion in acute morphine-treated rats by suppressing ERK and CREB phosphorylation in the basolateral amygdala.背侧海马N-甲基-D-天冬氨酸受体阻断通过抑制基底外侧杏仁核中的细胞外信号调节激酶（ERK）和环磷腺苷效应元件结合蛋白（CREB）磷酸化，损害急性吗啡处理大鼠中纳洛酮诱发的条件性位置厌恶的消退。
Br J Pharmacol. 2015 Jan;172(2):482-91. doi: 10.1111/bph.12671. Epub 2014 Jul 1.
7
The small GTPase RhoA, but not Rac1, is essential for conditioned aversive memory formation through regulation of actin rearrangements in rat dorsal hippocampus.小分子 GTP 酶 RhoA，但不是 Rac1，通过调节大鼠背侧海马中的肌动蛋白重排，对于条件性厌恶记忆的形成是必不可少的。
Acta Pharmacol Sin. 2013 Jun;34(6):811-8. doi: 10.1038/aps.2013.3. Epub 2013 Apr 8.
8
Glutamate mechanisms underlying opiate memories.谷氨酸在阿片类记忆中的作用机制。
Cold Spring Harb Perspect Med. 2012 Sep 1;2(9):a012088. doi: 10.1101/cshperspect.a012088.
9
Glutamate signaling through the kainate receptor enhances human immunoglobulin production.通过 kainate 受体的谷氨酸信号增强了人免疫球蛋白的产生。
J Neuroimmunol. 2011 Apr;233(1-2):80-9. doi: 10.1016/j.jneuroim.2010.11.014. Epub 2011 Jan 6.
本文引用的文献
1
The role of the dorsal and ventral hippocampus in fear and memory of a shock-probe experience.背侧和腹侧海马体在电击探针经历的恐惧和记忆中的作用。
Brain Res. 2009 Jan 28;1251:185-94. doi: 10.1016/j.brainres.2008.11.041. Epub 2008 Nov 24.
2
Glutamate transmission in addiction.成瘾中的谷氨酸传递。
Neuropharmacology. 2009;56 Suppl 1(Suppl 1):169-73. doi: 10.1016/j.neuropharm.2008.07.011. Epub 2008 Jul 16.
3
Hippocampal long-term synaptic plasticity and signal amplification of NMDA receptors.海马体长期突触可塑性与NMDA受体的信号放大
Crit Rev Neurobiol. 2006;18(1-2):71-84. doi: 10.1615/critrevneurobiol.v18.i1-2.80.
4
The role of dorsal hippocampus and basolateral amygdala NMDA receptors in the acquisition and retrieval of context and contextual fear memories.背侧海马体和基底外侧杏仁核NMDA受体在情境及情境恐惧记忆的获取与提取中的作用。
Behav Neurosci. 2007 Aug;121(4):721-31. doi: 10.1037/0735-7044.121.4.721.
5
NMDA receptors of dorsal hippocampus are involved in the acquisition, but not in the expression of morphine-induced place preference.背侧海马体的N-甲基-D-天冬氨酸受体参与吗啡诱导的位置偏爱形成，但不参与其表达。
Eur J Pharmacol. 2007 Jul 30;568(1-3):192-8. doi: 10.1016/j.ejphar.2007.04.015. Epub 2007 Apr 22.
6
Hippocampal activity, but not plasticity, is required for early consolidation of fear conditioning with a short trace interval.在短痕迹间隔的恐惧条件反射早期巩固过程中，需要海马体活动而非可塑性。
Eur J Neurosci. 2007 Apr;25(8):2483-90. doi: 10.1111/j.1460-9568.2007.05493.x.
7
GABA(A) receptors of hippocampal CA1 regions are involved in the acquisition and expression of morphine-induced place preference.海马体CA1区的γ-氨基丁酸A型（GABA(A)）受体参与吗啡诱导的位置偏爱行为的获得与表达。
Eur Neuropsychopharmacol. 2007 Jan;17(1):24-31. doi: 10.1016/j.euroneuro.2006.02.003. Epub 2006 Mar 6.
8
The glutamate release inhibitor riluzole attenuates the formation of conditioned place aversion induced by naloxone in rats undergoing a single morphine exposure.谷氨酸释放抑制剂利鲁唑可减轻单次吗啡暴露大鼠中由纳洛酮诱导的条件性位置厌恶的形成。
Brain Res. 2006 Jan 19;1069(1):120-6. doi: 10.1016/j.brainres.2005.11.058. Epub 2005 Dec 20.
9
Involvement of GABA(B) receptors of the dorsal hippocampus on the acquisition and expression of morphine-induced place preference in rats.大鼠背侧海马体GABA(B)受体对吗啡诱导的位置偏爱习得和表达的影响
Physiol Behav. 2006 Jan 30;87(1):31-8. doi: 10.1016/j.physbeh.2005.08.041. Epub 2005 Nov 7.
10
Synaptic mechanisms of associative memory in the amygdala.杏仁核中联想记忆的突触机制。
Neuron. 2005 Sep 15;47(6):783-6. doi: 10.1016/j.neuron.2005.08.009.
Zotero 插件