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7
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本文引用的文献

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The role of the dorsal and ventral hippocampus in fear and memory of a shock-probe experience.背侧和腹侧海马体在电击探针经历的恐惧和记忆中的作用。
Brain Res. 2009 Jan 28;1251:185-94. doi: 10.1016/j.brainres.2008.11.041. Epub 2008 Nov 24.
2
Glutamate transmission in addiction.成瘾中的谷氨酸传递。
Neuropharmacology. 2009;56 Suppl 1(Suppl 1):169-73. doi: 10.1016/j.neuropharm.2008.07.011. Epub 2008 Jul 16.
3
Hippocampal long-term synaptic plasticity and signal amplification of NMDA receptors.海马体长期突触可塑性与NMDA受体的信号放大
Crit Rev Neurobiol. 2006;18(1-2):71-84. doi: 10.1615/critrevneurobiol.v18.i1-2.80.
4
The role of dorsal hippocampus and basolateral amygdala NMDA receptors in the acquisition and retrieval of context and contextual fear memories.背侧海马体和基底外侧杏仁核NMDA受体在情境及情境恐惧记忆的获取与提取中的作用。
Behav Neurosci. 2007 Aug;121(4):721-31. doi: 10.1037/0735-7044.121.4.721.
5
NMDA receptors of dorsal hippocampus are involved in the acquisition, but not in the expression of morphine-induced place preference.背侧海马体的N-甲基-D-天冬氨酸受体参与吗啡诱导的位置偏爱形成，但不参与其表达。
Eur J Pharmacol. 2007 Jul 30;568(1-3):192-8. doi: 10.1016/j.ejphar.2007.04.015. Epub 2007 Apr 22.
6
Hippocampal activity, but not plasticity, is required for early consolidation of fear conditioning with a short trace interval.在短痕迹间隔的恐惧条件反射早期巩固过程中，需要海马体活动而非可塑性。
Eur J Neurosci. 2007 Apr;25(8):2483-90. doi: 10.1111/j.1460-9568.2007.05493.x.
7
GABA(A) receptors of hippocampal CA1 regions are involved in the acquisition and expression of morphine-induced place preference.海马体CA1区的γ-氨基丁酸A型（GABA(A)）受体参与吗啡诱导的位置偏爱行为的获得与表达。
Eur Neuropsychopharmacol. 2007 Jan;17(1):24-31. doi: 10.1016/j.euroneuro.2006.02.003. Epub 2006 Mar 6.
8
The glutamate release inhibitor riluzole attenuates the formation of conditioned place aversion induced by naloxone in rats undergoing a single morphine exposure.谷氨酸释放抑制剂利鲁唑可减轻单次吗啡暴露大鼠中由纳洛酮诱导的条件性位置厌恶的形成。
Brain Res. 2006 Jan 19;1069(1):120-6. doi: 10.1016/j.brainres.2005.11.058. Epub 2005 Dec 20.
9
Involvement of GABA(B) receptors of the dorsal hippocampus on the acquisition and expression of morphine-induced place preference in rats.大鼠背侧海马体GABA(B)受体对吗啡诱导的位置偏爱习得和表达的影响
Physiol Behav. 2006 Jan 30;87(1):31-8. doi: 10.1016/j.physbeh.2005.08.041. Epub 2005 Nov 7.
10
Synaptic mechanisms of associative memory in the amygdala.杏仁核中联想记忆的突触机制。
Neuron. 2005 Sep 15;47(6):783-6. doi: 10.1016/j.neuron.2005.08.009.

背侧海马中的谷氨酸受体介导急性吗啡戒断引起的条件性位置厌恶的获得，但不介导其表达。

Glutamate receptors in the dorsal hippocampus mediate the acquisition, but not the expression, of conditioned place aversion induced by acute morphine withdrawal in rats.

机构信息

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

出版信息

Acta Pharmacol Sin. 2009 Oct;30(10):1385-91. doi: 10.1038/aps.2009.130. Epub 2009 Sep 21.

DOI:10.1038/aps.2009.130
PMID:19767765
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4007332/
Abstract

AIM

To evaluate the role of glutamate receptors in the dorsal hippocampus (DH) in the motivational component of morphine withdrawal.

METHODS

NMDA receptor antagonist D-AP5 (5 microg/0.5 microL per side) or AMPA receptor antagonist NBQX (2 microg/0.5 microL per side) was microinjected into DH of rats. Conditioned place aversion (CPA) induced by naloxone-precipitated morphine withdrawal were assessed.

RESULTS

Preconditioning microinjection of D-AP5 or NBQX into the DH impaired the acquisition of CPA in acute morphine-dependent rats. However, intra-DH microinjection of D-AP5 or NBQX after conditioning but before the testing session had no effect on the expression of CPA.

CONCLUSION

Our results suggest that NMDA and AMPA receptors in the dorsal hippocampus are involved in the acquisition, but not in the expression, of the negative motivational components of acute morphine withdrawal in rats.

摘要

目的

评估背侧海马（DH）中的谷氨酸受体在吗啡戒断的动机成分中的作用。

方法

将 NMDA 受体拮抗剂 D-AP5（每侧 5μg/0.5μL）或 AMPA 受体拮抗剂 NBQX（每侧 2μg/0.5μL）微注射到大鼠的 DH 中。评估纳洛酮诱发的吗啡戒断引起的条件性位置厌恶（CPA）。

结果

在急性吗啡依赖大鼠中，预先将 D-AP5 或 NBQX 微注射到 DH 中会损害 CPA 的获得。然而，在条件作用后但在测试阶段之前将 D-AP5 或 NBQX 微注射到 DH 中对 CPA 的表达没有影响。

结论

我们的结果表明，背侧海马中的 NMDA 和 AMPA 受体参与了大鼠急性吗啡戒断的负性动机成分的获得，但不参与其表达。