Kalivas Peter W, Lalumiere Ryan T, Knackstedt Lori, Shen Haowei
Department of Neurosciences, 173 Ashley Ave, BSB410, Medical University of South Carolina, Charleston, SC 29464, USA.
Neuropharmacology. 2009;56 Suppl 1(Suppl 1):169-73. doi: 10.1016/j.neuropharm.2008.07.011. Epub 2008 Jul 16.
Cortico-striatal glutamate transmission has been implicated in both the initiation and expression of addiction related behaviors, such as locomotor sensitization and drug-seeking. While glutamate transmission onto dopamine cells in the ventral tegmental area undergoes transient plasticity important for establishing addiction-related behaviors, glutamatergic plasticity in the nucleus accumbens is critical for the expression of these behaviors. This information points to the value of exploring pharmacotherapeutic manipulation of glutamate plasticity in treating drug addiction.
皮质-纹状体谷氨酸能传递与成瘾相关行为的启动和表达有关，如运动敏化和觅药行为。虽然腹侧被盖区多巴胺能细胞上的谷氨酸能传递经历短暂可塑性，对建立成瘾相关行为很重要，但伏隔核中的谷氨酸能可塑性对这些行为的表达至关重要。这一信息表明探索谷氨酸能可塑性的药物治疗性调控在治疗药物成瘾方面的价值。
