佐治亚州东南部的结缔组织病。一项基于社区的免疫遗传标记和自身抗体研究。
Connective tissue disease in southeast Georgia. A community based study of immunogenetic markers and autoantibodies.
作者信息
Arnett F C, Bias W B, McLean R H, Engel M, Duvic M, Goldstein R, Freni-Titulaer L, McKinley T W, Hochberg M C
机构信息
Department of Internal Medicine, University of Texas Medical School, Houston 77225.
出版信息
J Rheumatol. 1990 Aug;17(8):1029-35.
HLA antigens, C4 allotypes and T cell antigen receptor (TcR)beta DNA polymorphisms were determined in a community based study of connective tissue diseases (CTD). HLA-B8, DR3 and C4A null phenotypes occurred frequently in Caucasian patients with CTD, especially those with systemic lupus erythematosus (SLE), but were also more commonly found among healthy white controls of this southeast Georgia community. TcR beta gene polymorphisms also showed differential segregation patterns between patients with SLE and scleroderma. High frequencies of ANA and anti-ssDNA antibodies occurred among apparently healthy family members and local controls. Genetic factors predisposing to CTD in a community setting appear to be similar to those reported from referral centers.
在一项基于社区的结缔组织病（CTD）研究中，对HLA抗原、C4同种异型以及T细胞抗原受体（TcR）β DNA多态性进行了测定。HLA - B8、DR3和C4A无效表型在患有CTD的白种人患者中频繁出现，尤其是系统性红斑狼疮（SLE）患者，但在佐治亚州东南部这个社区的健康白人对照中也更为常见。TcRβ基因多态性在SLE患者和硬皮病患者之间也表现出不同的分离模式。在明显健康的家庭成员和当地对照中，ANA和抗ssDNA抗体的频率较高。在社区环境中，易患CTD的遗传因素似乎与转诊中心报告的因素相似。
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