VCD法测定斯替泊醇的绝对构型
VCD determination of the absolute configuration of stypotriol.
作者信息
Muñoz Marcelo A, Areche Carlos, San-Martín Aurelio, Rovirosa Juana, Joseph-Nathan Pedro
机构信息
Instituto de Química, Facultad de Ciencias, Universidad Austral de Chile, Casilla 567, Valdivia, Chile.
出版信息
Nat Prod Commun. 2009 Aug;4(8):1037-40.
The absolute configuration of the pentacyclic ichthyotoxin stypotriol, a constituent of Stypopodium zonale, was deduced to be 3S,5R,8R,9R,10S,13S,14S-(-)-1 by vibrational circular dichroism spectroscopy of the derived triacetate 2 in comparison to DFT B3LYP/DGDZVP calculations. Compound 2, C33H46O7 having 300 electrons, is the largest natural product successfully studied by VCD to date.
通过将衍生的三乙酸酯2与DFT B3LYP/DGDZVP计算结果进行比较，利用振动圆二色光谱法推导出了带状沙海葵（Stypopodium zonale）的成分五环鱼毒素stypotriol的绝对构型为3S,5R,8R,9R,10S,13S,14S-(-)-1。化合物2（C33H46O7，有300个电子）是迄今为止通过VCD成功研究的最大天然产物。
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