Gazit Roi, Weissman Irving L, Rossi Derrick J
Immune Disease Institute, Harvard Stem Cell Institute, and Department of Pathology, Harvard Medical School, Boston, MA.
Semin Hematol. 2008 Oct;45(4):218-24. doi: 10.1053/j.seminhematol.2008.07.010.
The etiology of the age-associated pathophysiological changes of the hematopoietic system including the onset of anemia, diminished adaptive immune competence, and myelogenous disease development are underwritten by the loss of normal homeostatic control. As tissue and organ homeostasis in adults is primarily mediated by the activity of stem and progenitor cells, it has been suggested that the imbalances accompanying aging of the hematopoietic system may stem from alterations in the prevalence and/or functional capacity of hematopoietic stem cells (HSCs) and progenitors. In this review, we examine evidence implicating a role for stem cells in the aging of the hematopoietic system, and focus on the mechanisms suggested to contribute to stem cell aging.
造血系统与年龄相关的病理生理变化的病因，包括贫血的发生、适应性免疫能力的下降以及骨髓性疾病的发展，都归因于正常稳态控制的丧失。由于成体组织和器官的稳态主要由干细胞和祖细胞的活性介导，因此有人提出，造血系统衰老伴随的失衡可能源于造血干细胞（HSCs）和祖细胞的数量和/或功能能力的改变。在这篇综述中，我们研究了表明干细胞在造血系统衰老中起作用的证据，并聚焦于被认为导致干细胞衰老的机制。
