黑质多巴胺能神经元是否能区分奖励和惩罚？
Do substantia nigra dopaminergic neurons differentiate between reward and punishment?
机构信息
Departments of Cognitive & Linguistic Sciences, Psychology, and Psychiatry, Brown University, Providence, RI 02912-1978, USA.
出版信息
J Mol Cell Biol. 2009 Oct;1(1):15-6. doi: 10.1093/jmcb/mjp010. Epub 2009 Sep 21.
PMID:19770170
Abstract
The activity of dopaminergic neurons are thought to be increased by stimuli that predict reward and decreased by stimuli that predict aversive outcomes. Recent work by Matsumoto and Hikosaka challenges this model by asserting that stimuli associated with either rewarding or aversive outcomes increase the activity of dopaminergic neurons in the substantia nigra pars compacta.
摘要
人们认为，预测奖励的刺激会增加多巴胺能神经元的活动，而预测厌恶结果的刺激则会降低多巴胺能神经元的活动。松本和希科萨卡最近的研究工作挑战了这一模型，他们断言，与奖励或厌恶结果相关的刺激会增加黑质致密部多巴胺能神经元的活动。
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