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本文引用的文献

1
Biocide-tolerant multidrug-resistant Acinetobacter baumannii clinical strains are associated with higher biofilm formation.耐杀菌剂的多重耐药鲍曼不动杆菌临床菌株与更高的生物膜形成有关。
J Hosp Infect. 2009 Nov;73(3):287-9. doi: 10.1016/j.jhin.2009.07.015. Epub 2009 Sep 16.
2
CraA, a major facilitator superfamily efflux pump associated with chloramphenicol resistance in Acinetobacter baumannii.CraA，一种与鲍曼不动杆菌中氯霉素耐药性相关的主要易化子超家族外排泵。
Antimicrob Agents Chemother. 2009 Sep;53(9):4013-4. doi: 10.1128/AAC.00584-09. Epub 2009 Jul 6.
3
Genetic relatedness and molecular characterization of multidrug resistant Acinetobacter baumannii isolated in central Ohio, USA.美国俄亥俄州中部分离出的多重耐药鲍曼不动杆菌的遗传相关性及分子特征
Ann Clin Microbiol Antimicrob. 2009 Jun 17;8:21. doi: 10.1186/1476-0711-8-21.
4
Multiple sequence alignment using ClustalW and ClustalX.使用ClustalW和ClustalX进行多序列比对。
Curr Protoc Bioinformatics. 2002 Aug;Chapter 2:Unit 2.3. doi: 10.1002/0471250953.bi0203s00.
5
Genetic basis of multidrug resistance in Acinetobacter baumannii clinical isolates at a tertiary medical center in Pennsylvania.宾夕法尼亚州一家三级医疗中心鲍曼不动杆菌临床分离株多药耐药的遗传基础。
Antimicrob Agents Chemother. 2008 Nov;52(11):3837-43. doi: 10.1128/AAC.00570-08. Epub 2008 Aug 25.
6
Acinetobacter baumannii: emergence of a successful pathogen.鲍曼不动杆菌：一种成功病原体的出现
Clin Microbiol Rev. 2008 Jul;21(3):538-82. doi: 10.1128/CMR.00058-07.
7
Correlation of antimicrobial resistance with beta-lactamases, the OmpA-like porin, and efflux pumps in clinical isolates of Acinetobacter baumannii endemic to New York City.纽约市地方性鲍曼不动杆菌临床分离株中抗生素耐药性与β-内酰胺酶、类OmpA孔蛋白及外排泵的相关性
Antimicrob Agents Chemother. 2008 Sep;52(9):2999-3005. doi: 10.1128/AAC.01684-07. Epub 2008 Jun 30.
8
Phenotypic and molecular characterization of Acinetobacter baumannii clinical isolates from nosocomial outbreaks in Los Angeles County, California.加利福尼亚州洛杉矶县医院感染暴发中鲍曼不动杆菌临床分离株的表型和分子特征
J Clin Microbiol. 2008 Aug;46(8):2499-507. doi: 10.1128/JCM.00367-08. Epub 2008 Jun 4.
9
Whole-genome pyrosequencing of an epidemic multidrug-resistant Acinetobacter baumannii strain belonging to the European clone II group.一株属于欧洲克隆II群的流行多重耐药鲍曼不动杆菌的全基因组焦磷酸测序
Antimicrob Agents Chemother. 2008 Jul;52(7):2616-25. doi: 10.1128/AAC.01643-07. Epub 2008 Apr 14.
10
Functional gene cloning and characterization of the SsmE multidrug efflux pump from Serratia marcescens.粘质沙雷氏菌SsmE多药外排泵的功能基因克隆与特性分析
Biol Pharm Bull. 2008 Mar;31(3):516-9. doi: 10.1248/bpb.31.516.

AbeS 是 SMR 家族转运蛋白的一种新型外排泵，在鲍曼不动杆菌对抗菌药物的耐药性中起作用。

Role of AbeS, a novel efflux pump of the SMR family of transporters, in resistance to antimicrobial agents in Acinetobacter baumannii.

机构信息

Department of Veterinary Preventive Medicine, College of Veterinary Medicine, Columbus, OH 43210, USA.

出版信息

Antimicrob Agents Chemother. 2009 Dec;53(12):5312-6. doi: 10.1128/AAC.00748-09. Epub 2009 Sep 21.

DOI:10.1128/AAC.00748-09
PMID:19770280
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2786332/
Abstract

In this study, a chromosomally encoded putative drug efflux pump of the SMR family, named AbeS, from a multidrug-resistant strain of Acinetobacter baumannii was characterized to elucidate its role in antimicrobial resistance. Expression of the cloned abeS gene in hypersensitive Escherichia coli host KAM32 resulted in decreased susceptibility to various classes of antimicrobial agents, detergents, and dyes. Deletion of the abeS gene in A. baumannii confirmed its role in conferring resistance to these compounds.

摘要

在这项研究中，从一株多药耐药鲍曼不动杆菌中鉴定出一种染色体编码的 SMR 家族假定药物外排泵 AbeS，以阐明其在抗菌药物耐药性中的作用。在敏感的大肠杆菌宿主 KAM32 中表达克隆的 abeS 基因导致对各种类别的抗菌药物、去污剂和染料的敏感性降低。在鲍曼不动杆菌中缺失 abeS 基因证实了其在赋予这些化合物耐药性中的作用。