Medical College of Wisconsin, Department of Pediatrics, Children's Research Institute, Children's Hospital and Health Systems, Milwaukee, Wisconsin 53226-4801, USA.
Toxicol Sci. 2010 Jan;113(1):4-26. doi: 10.1093/toxsci/kfp217. Epub 2009 Sep 21.
Assessing the risk profiles of potentially sensitive populations requires a "tool chest" of methodological approaches to adequately characterize and evaluate these populations. At present, there is an extensive body of literature on methodologies that apply to the evaluation of the pediatric population. The Health and Environmental Sciences Institute Subcommittee on Risk Assessment of Sensitive Populations evaluated key references in the area of pediatric risk to identify a spectrum of methodological approaches. These approaches are considered in this article for their potential to be extrapolated for the identification and assessment of other sensitive populations. Recommendations as to future research needs and/or alternate methodological considerations are also made.
评估潜在敏感人群的风险概况需要一套方法学方法的“工具箱”，以充分描述和评估这些人群。目前，有大量关于适用于儿科人群评估的方法学的文献。健康和环境科学研究所敏感人群风险评估小组委员会评估了儿科风险领域的关键参考文献，以确定一系列方法学方法。本文考虑了这些方法，因为它们有可能被推断用于识别和评估其他敏感人群。还就未来的研究需求和/或替代方法学考虑提出了建议。
