致病抗体是脊髓损伤的积极参与者。
Pathogenic antibodies are active participants in spinal cord injury.
机构信息
BioTherapeutics Research Laboratory, Molecular Brain Research Group, Robarts Research Institute and Department of Microbiology and Immunology,The University of Western Ontario, 100 Perth Drive, London, Ontario, Canada.
出版信息
J Clin Invest. 2009 Oct;119(10):2881-4. doi: 10.1172/JCI40839. Epub 2009 Sep 21.
Abstract
The role of B cells and autoimmunity as contributing factors to poor neurological outcomes following spinal cord injury (SCI) is poorly understood. The study by Ankeny et al., in this issue of the JCI, identifies a new immunopathological mechanism arising after SCI in mice (see the related article beginning on page 2990). The study shows that B cells produce pathogenic antibodies that impair lesion repair, resulting in worse neurological outcome. This new understanding of SCI disease pathogenesis, if confirmed in humans, reveals potential avenues for the development of novel neuroprotective immunotherapies.
摘要
B 细胞和自身免疫在脊髓损伤 (SCI) 后神经功能不良结局中的作用尚未完全阐明。Ankeny 等人在本期《临床研究杂志》中的研究，在 SCI 后的小鼠模型中鉴定出一种新的免疫病理机制（见 2990 页相关文章）。该研究表明，B 细胞产生致病性抗体，损害损伤修复，导致更差的神经功能结局。如果在人类中得到证实，对 SCI 发病机制的这一新认识，揭示了开发新型神经保护免疫疗法的潜在途径。
相似文献
1
Pathogenic antibodies are active participants in spinal cord injury.致病抗体是脊髓损伤的积极参与者。
J Clin Invest. 2009 Oct;119(10):2881-4. doi: 10.1172/JCI40839. Epub 2009 Sep 21.
2
B cells produce pathogenic antibodies and impair recovery after spinal cord injury in mice.B 细胞产生致病性抗体，并损害小鼠脊髓损伤后的恢复。
J Clin Invest. 2009 Oct;119(10):2990-9. doi: 10.1172/JCI39780. Epub 2009 Sep 21.
3
Spinal cord injury triggers systemic autoimmunity: evidence for chronic B lymphocyte activation and lupus-like autoantibody synthesis.脊髓损伤引发全身性自身免疫：慢性B淋巴细胞活化和狼疮样自身抗体合成的证据。
J Neurochem. 2006 Nov;99(4):1073-87. doi: 10.1111/j.1471-4159.2006.04147.x.
4
B-cell maturation antigen, a proliferation-inducing ligand, and B-cell activating factor are candidate mediators of spinal cord injury-induced autoimmunity.B 细胞成熟抗原、增殖诱导配体和 B 细胞激活因子是脊髓损伤诱导自身免疫的候选介质。
J Neurotrauma. 2013 Mar 15;30(6):434-40. doi: 10.1089/neu.2012.2501. Epub 2013 Mar 28.
5
Natural IgM antibodies that bind neoepitopes exposed as a result of spinal cord injury , drive secondary injury by activating complement.与脊髓损伤后暴露的新表位结合的天然IgM抗体，通过激活补体驱动继发性损伤。
J Neuroinflammation. 2017 Jun 19;14(1):120. doi: 10.1186/s12974-017-0894-6.
6
Improved regeneration after spinal cord injury in mice lacking functional T- and B-lymphocytes.T 细胞和 B 细胞功能缺失的小鼠脊髓损伤后再生能力增强。
Exp Neurol. 2012 Oct;237(2):274-85. doi: 10.1016/j.expneurol.2012.07.016. Epub 2012 Jul 31.
7
Immunotherapy strategies for spinal cord injury.脊髓损伤的免疫治疗策略。
Curr Pharm Biotechnol. 2015;16(6):492-505. doi: 10.2174/138920101606150407112646.
8
Gene-Silencing Screen for Mammalian Axon Regeneration Identifies Inpp5f (Sac2) as an Endogenous Suppressor of Repair after Spinal Cord Injury.用于哺乳动物轴突再生的基因沉默筛选确定Inpp5f（Sac2）是脊髓损伤后修复的内源性抑制因子。
J Neurosci. 2015 Jul 22;35(29):10429-39. doi: 10.1523/JNEUROSCI.1718-15.2015.
9
Therapeutic Antibodies for Spinal Cord Injury.用于脊髓损伤的治疗性抗体。
CNS Neurol Disord Drug Targets. 2017;16(1):51-64. doi: 10.2174/1871527315666160915150754.
10
Characterization of the Antibody Response after Cervical Spinal Cord Injury.颈脊髓损伤后抗体反应的特征
J Neurotrauma. 2017 Mar 15;34(6):1209-1226. doi: 10.1089/neu.2016.4498. Epub 2016 Dec 21.
引用本文的文献
1
Title: Immunotherapy; a ground-breaking remedy for spinal cord injury with stumbling blocks: An overview.标题：免疫疗法：一种治疗脊髓损伤的开创性疗法及其障碍概述
Front Pharmacol. 2023 Jan 25;14:1110008. doi: 10.3389/fphar.2023.1110008. eCollection 2023.
2
Inflammation and Oxidative Stress as Common Mechanisms of Pulmonary, Autonomic and Musculoskeletal Dysfunction after Spinal Cord Injury.炎症和氧化应激作为脊髓损伤后肺部、自主神经和肌肉骨骼功能障碍的共同机制
Biology (Basel). 2022 Apr 1;11(4):550. doi: 10.3390/biology11040550.
3
Inhibition of Bruton Tyrosine Kinase Reduces Neuroimmune Cascade and Promotes Recovery after Spinal Cord Injury.抑制布鲁顿酪氨酸激酶可减少神经免疫级联反应，并促进脊髓损伤后的恢复。
Int J Mol Sci. 2021 Dec 29;23(1):355. doi: 10.3390/ijms23010355.
4
Metformin prevents BAFF activation of Erk1/2 from B-cell proliferation and survival by impeding mTOR-PTEN/Akt signaling pathway.二甲双胍通过抑制 mTOR-PTEN/Akt 信号通路来阻止 BAFF 激活 Erk1/2 从而阻止 B 细胞增殖和存活。
Int Immunopharmacol. 2021 Jul;96:107771. doi: 10.1016/j.intimp.2021.107771. Epub 2021 May 15.
5
TMEM176A and TMEM176B Are Candidate Regulators of Inhibition of Dendritic Cell Maturation and Function after Chronic Spinal Cord Injury.TMEM176A 和 TMEM176B 是慢性脊髓损伤后抑制树突状细胞成熟和功能的候选调节剂。
J Neurotrauma. 2020 Feb 1;37(3):528-533. doi: 10.1089/neu.2019.6498. Epub 2019 Sep 18.
6
B Cell-Activating Factor Is Associated with Testosterone and Smoking Status in Non-Ambulatory Men with Chronic Spinal Cord Injury.B 细胞激活因子与非卧床慢性脊髓损伤男性的睾酮和吸烟状况相关。
J Neurotrauma. 2019 Dec 15;36(24):3332-3337. doi: 10.1089/neu.2018.6221. Epub 2019 Jun 17.
7
Repositioning Flubendazole for Spinal Cord Injury.将氟苯达唑重新定位用于治疗脊髓损伤。
J Neurotrauma. 2019 Sep 15;36(18):2618-2630. doi: 10.1089/neu.2018.6160. Epub 2019 Mar 15.
8
Antibody profiling identifies novel antigenic targets in spinal cord injury patients.抗体谱分析确定了脊髓损伤患者中的新型抗原靶点。
J Neuroinflammation. 2016 Sep 13;13(1):243. doi: 10.1186/s12974-016-0713-5.
9
B-Cell Depletion with CD20 Antibodies as New Approach in the Treatment of Inflammatory and Immunological Events Associated with Spinal Cord Injury.使用CD20抗体清除B细胞作为治疗与脊髓损伤相关的炎症和免疫事件的新方法。
Neurotherapeutics. 2016 Oct;13(4):880-894. doi: 10.1007/s13311-016-0446-2.
10
Spinal cord injury is related to an increased risk of multiple sclerosis: a population-based, propensity score-matched, longitudinal follow-up study.脊髓损伤与多发性硬化症风险增加相关：一项基于人群的倾向评分匹配纵向随访研究。
J Neurotrauma. 2015 May 1;32(9):655-9. doi: 10.1089/neu.2014.3723. Epub 2015 Mar 6.
本文引用的文献
1
B cells produce pathogenic antibodies and impair recovery after spinal cord injury in mice.B 细胞产生致病性抗体，并损害小鼠脊髓损伤后的恢复。
J Clin Invest. 2009 Oct;119(10):2990-9. doi: 10.1172/JCI39780. Epub 2009 Sep 21.
2
The immunoregulatory enzyme IDO paradoxically drives B cell-mediated autoimmunity.免疫调节酶吲哚胺2,3-双加氧酶（IDO）反常地驱动B细胞介导的自身免疫。
J Immunol. 2009 Jun 15;182(12):7509-17. doi: 10.4049/jimmunol.0804328.
3
Cholinergic control of inflammation.炎症的胆碱能控制
J Intern Med. 2009 Jun;265(6):663-79. doi: 10.1111/j.1365-2796.2009.02098.x.
4
Systemic inflammatory response following acute traumatic brain injury.急性创伤性脑损伤后的全身炎症反应。
Front Biosci (Landmark Ed). 2009 Jan 1;14(10):3795-813. doi: 10.2741/3489.
5
B-lymphocyte depletion for the treatment of multiple sclerosis: now things really get interesting.B淋巴细胞清除疗法治疗多发性硬化症：现在事情真的变得有趣起来了。
Expert Rev Neurother. 2009 Mar;9(3):309-12. doi: 10.1586/14737175.9.3.309.
6
IDO: a double-edged sword for T(H)1/T(H)2 regulation.吲哚胺 2,3-双加氧酶：T(H)1/T(H)2 调节的双刃剑
Immunol Lett. 2008 Nov 16;121(1):1-6. doi: 10.1016/j.imlet.2008.08.008. Epub 2008 Sep 29.
7
B cells as therapeutic targets in autoimmune neurological disorders.B细胞作为自身免疫性神经系统疾病的治疗靶点。
Nat Clin Pract Neurol. 2008 Oct;4(10):557-67. doi: 10.1038/ncpneuro0901. Epub 2008 Sep 23.
8
Immune depression syndrome following human spinal cord injury (SCI): a pilot study.人类脊髓损伤（SCI）后的免疫抑制综合征：一项初步研究。
Neuroscience. 2009 Feb 6;158(3):1194-9. doi: 10.1016/j.neuroscience.2008.08.021. Epub 2008 Aug 22.
9
Nature and functions of autoantibodies.自身抗体的性质与功能。
Nat Clin Pract Rheumatol. 2008 Sep;4(9):491-8. doi: 10.1038/ncprheum0895.
10
Spotlight on anti-CD20.聚焦抗CD20
Int MS J. 2008 Mar;15(1):19-25.
Zotero 插件