Koul Roshan
Department of Child Health, College of Medicine and Health Sciences, Sultan Qaboos University Hospital, Muscat, Oman.
Neurol India. 2009 Jul-Aug;57(4):460-3. doi: 10.4103/0028-3886.55595.
Eight children with pyridoxine-dependent seizures (PDS) were seen over a period of 10 years. Of those children, 6 are on regular follow-up. Four of the children were seen in one family. All the patients presented with refractory seizures, mainly neonatal status epilepticus. Though PDS is a rare condition, it must be considered in all cases with refractory seizures, particularly in children younger than 3 years. When confirming a diagnosis, oral pyridoxine is as effective as intravenous pyridoxine.
在10年期间共诊治了8例吡哆醇依赖性癫痫（PDS）患儿。其中6例患儿正在接受定期随访。有4名患儿来自同一个家庭。所有患者均表现为难治性癫痫发作，主要为新生儿癫痫持续状态。尽管PDS是一种罕见疾病，但在所有难治性癫痫发作的病例中都必须考虑到，尤其是3岁以下的儿童。确诊时，口服吡哆醇与静脉注射吡哆醇效果相同。
