Murty V S S Yerramilli, Kishore M S S, Patel Manisha R
Department of Pediatrics, Maharajhas Institute of Medical Sciences, Vizianagaram, Andhra Pradesh, India.
J Clin Neonatol. 2013 Jan;2(1):39-41. doi: 10.4103/2249-4847.109248.
Pyridoxine-dependent seizures is a rare cause of recurrent seizures in neonatal period and resistant to most of the antiepileptic medications, but respond to administration of pyridoxine. We report a male infant who had neonatal seizures which were initially responsive to anticonvulsants and later became unresponsive and presented at 45 days of life with seizures. These seizures were not responding to any anticonvulsant but responded to pyridoxine. After discharge parents inadvertently stopped pyridoxine and the infant presented with seizures once again. These seizures were promptly controlled with readministration of pyridoxine confirming the diagnosis of pyridoxine-dependant seizures.
维生素B6依赖型癫痫是新生儿期反复癫痫发作的罕见原因，对大多数抗癫痫药物耐药，但对维生素B6治疗有反应。我们报告一名男婴，其新生儿期癫痫发作最初对抗惊厥药物有反应，后来无反应，在45日龄时出现癫痫发作。这些癫痫发作对抗癫痫药物均无反应，但对维生素B6有反应。出院后，家长无意中停用了维生素B6，婴儿再次出现癫痫发作。再次给予维生素B6后，癫痫发作迅速得到控制，从而确诊为维生素B6依赖型癫痫。
