Hämmerling G J, Moreno J
Institute for Immunology and Genetics, German Cancer Research Center, Heidelberg.
Immunol Today. 1990 Oct;11(10):337-40. doi: 10.1016/0167-5699(90)90132-s.
The existence of different pathways of antigen presentation by class I and class II molecules raises two fundamental questions. (1) Why are class II, but not class I molecules, transported to the endosomal compartment where the exogenous antigen is met? (2) What are the mechanisms that prevent class II molecules from being occupied and blocked by endogenous peptides before they reach endosomes? These and other questions were discussed at the recent 7th International HLA/H-2 Workshop. In round table discussions particular attention was paid to the class-II-associated invariant chain, because it was considered that this molecule was a likely candidate to explain some of the differences of class I and class II molecules in antigen presentation.
I类和II类分子存在不同的抗原呈递途径，这引发了两个基本问题。（1）为什么II类分子而非I类分子会被转运至与外源性抗原相遇的内体区室？（2）在II类分子到达内体之前，阻止其被内源性肽占据和阻断的机制是什么？在最近召开的第七届国际HLA/H-2研讨会上，对这些问题及其他问题进行了讨论。在圆桌讨论中，特别关注了与II类分子相关的恒定链，因为人们认为该分子可能是解释I类和II类分子在抗原呈递方面某些差异的候选者。
