Teyton L, O'Sullivan D, Dickson P W, Lotteau V, Sette A, Fink P, Peterson P A
Department of Immunology, Research Institute of Scripps Clinic, La Jolla, California 92037.
Nature. 1990 Nov 1;348(6296):39-44. doi: 10.1038/348039a0.
Class I MHC molecules acquire peptides from endogenously synthesized proteins, whereas class II antigens present peptides derived from extracellular compartment molecules. This dichotomy is due to the fact that the invariant chain associates with class II molecules in the endoplasmic reticulum, preventing binding of endogenous peptides. The mutually exclusive binding of peptide and invariant chain to class II molecules suggests that the invariant chain might play a part in autoimmune disease.
I类主要组织相容性复合体（MHC）分子从内源性合成的蛋白质中获取肽段，而II类抗原呈递来自细胞外区室分子的肽段。这种二分法是由于恒定链在内质网中与II类分子结合，从而阻止内源性肽段的结合。肽段和恒定链与II类分子的相互排斥结合表明恒定链可能在自身免疫性疾病中起作用。
