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Increased insulin dose requirement of long-acting insulin analogues in obese patients with type 2 diabetes.

作者信息

Schmid C, Krayenbühl P, Wiesli P

出版信息

Diabetologia. 2009 Dec;52(12):2668-9. doi: 10.1007/s00125-009-1534-1. Epub 2009 Sep 24.

DOI:10.1007/s00125-009-1534-1
PMID:19774359
Abstract
摘要

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1
Increased insulin dose requirement of long-acting insulin analogues in obese patients with type 2 diabetes.2型糖尿病肥胖患者长效胰岛素类似物的胰岛素剂量需求增加。
Diabetologia. 2009 Dec;52(12):2668-9. doi: 10.1007/s00125-009-1534-1. Epub 2009 Sep 24.
2
Long-acting insulin analogs versus human insulins.长效胰岛素类似物与人胰岛素的比较。
Diabetes Technol Ther. 2008 Oct;10(5):331-2. doi: 10.1089/dia.2008.0071.
3
Long-acting insulin analogues versus NPH insulin (human isophane insulin) for type 2 diabetes mellitus.长效胰岛素类似物与NPH胰岛素（人低精蛋白胰岛素）治疗2型糖尿病的比较
Cochrane Database Syst Rev. 2007 Apr 18(2):CD005613. doi: 10.1002/14651858.CD005613.pub3.
4
Long-acting insulin analogues and diabetic retinopathy: a retrospective cohort study.长效胰岛素类似物与糖尿病视网膜病变：一项回顾性队列研究。
Clin Ther. 2014 Sep 1;36(9):1255-68. doi: 10.1016/j.clinthera.2014.06.031. Epub 2014 Jul 28.
5
Insulin combination therapy in type 2 diabetes mellitus.
Ann Intern Med. 2004 Apr 20;140(8):666; author reply 667. doi: 10.7326/0003-4819-140-8-200404200-00023.
6
Insulin combination therapy in type 2 diabetes mellitus.
Ann Intern Med. 2004 Apr 20;140(8):666-7; author reply 667. doi: 10.7326/0003-4819-140-8-200404200-00024.
7
[Insulin detemir compared with NPH insulin. No significant differences identified in the studies].[地特胰岛素与中性鱼精蛋白锌胰岛素的比较。研究中未发现显著差异]
Lakartidningen. 2006;103(18):1417, 1419-22, 1424-6.
8
Re: trial comparing insulin detemir with insulin glargine.关于：比较地特胰岛素与甘精胰岛素的试验。
Clin Ther. 2009 May;31(5):1124-5; author reply 1125-6. doi: 10.1016/j.clinthera.2009.05.004.
9
Lower within-subject variability of insulin detemir in comparison to NPH insulin and insulin glargine in people with type 1 diabetes.与NPH胰岛素和甘精胰岛素相比，地特胰岛素在1型糖尿病患者中的个体内变异性更低。
Diabetes. 2004 Jun;53(6):1614-20. doi: 10.2337/diabetes.53.6.1614.
10
[Combination therapy with oral antidiabetics].[口服抗糖尿病药物联合治疗]
MMW Fortschr Med. 2007 Jun 21;149(25-26):52-3.

引用本文的文献

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Prevention of tumour cell apoptosis associated with sustained protein kinase B phosphorylation is more sensitive to regulation by insulin signalling than stimulation of proliferation and extracellular signal-regulated kinase.与持续的蛋白激酶B磷酸化相关的肿瘤细胞凋亡的预防，相较于增殖刺激和细胞外信号调节激酶，对胰岛素信号调节更为敏感。
Mol Cell Biochem. 2017 Aug;432(1-2):41-54. doi: 10.1007/s11010-017-2996-y. Epub 2017 Mar 18.
2
Impact of patient and treatment characteristics on glycemic control and hypoglycemia in patients with type 2 diabetes initiated to insulin glargine or NPH: A post hoc, pooled, patient-level analysis of 6 randomized controlled trials.甘精胰岛素或中性鱼精蛋白锌胰岛素起始治疗的2型糖尿病患者中患者及治疗特征对血糖控制和低血糖的影响：6项随机对照试验的事后汇总患者水平分析
Medicine (Baltimore). 2017 Feb;96(5):e6022. doi: 10.1097/MD.0000000000006022.
3

本文引用的文献

1
Does diabetes therapy influence the risk of cancer?糖尿病治疗会影响患癌风险吗？
Diabetologia. 2009 Sep;52(9):1699-708. doi: 10.1007/s00125-009-1441-5.
2
Omitting breakfast and lunch after injection of different long-acting insulin preparations at bedtime: a prospective study in patients with type 2 diabetes.睡前注射不同长效胰岛素制剂后省略早餐和午餐：2 型糖尿病患者的前瞻性研究。
Diabetologia. 2009 Sep;52(9):1816-9. doi: 10.1007/s00125-009-1439-z. Epub 2009 Jun 30.
3
Less weight gain and hypoglycaemia with once-daily insulin detemir than NPH insulin in intensification of insulin therapy in overweight Type 2 diabetes patients: the PREDICTIVE BMI clinical trial.
Differential effects of adiposity on pharmacodynamics of basal insulins NPH, glargine, and detemir in type 2 diabetes mellitus.肥胖对 2 型糖尿病患者基础胰岛素 NPH、甘精胰岛素和地特胰岛素药效学的差异影响。
Diabetes Care. 2011 Dec;34(12):2521-3. doi: 10.2337/dc11-1064. Epub 2011 Oct 4.
在超重2型糖尿病患者强化胰岛素治疗中，与中性鱼精蛋白锌胰岛素相比，每日一次地特胰岛素体重增加更少且低血糖发生率更低：PREDICTIVE BMI临床试验
Diabet Med. 2008 Aug;25(8):916-23. doi: 10.1111/j.1464-5491.2008.02483.x.
4
A 26-week, randomized, parallel, treat-to-target trial comparing insulin detemir with NPH insulin as add-on therapy to oral glucose-lowering drugs in insulin-naive people with type 2 diabetes.一项为期26周的随机、平行、达标治疗试验，比较地特胰岛素与中性鱼精蛋白锌胰岛素作为口服降糖药物的附加疗法，用于初治2型糖尿病患者。
Diabetes Care. 2006 Jun;29(6):1269-74. doi: 10.2337/dc05-1365.
5
Insulin glargine or NPH combined with metformin in type 2 diabetes: the LANMET study.甘精胰岛素或中性鱼精蛋白锌胰岛素联合二甲双胍治疗2型糖尿病：LANMET研究
Diabetologia. 2006 Mar;49(3):442-51. doi: 10.1007/s00125-005-0132-0. Epub 2006 Feb 3.
6
The treat-to-target trial: randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patients.达标治疗试验：在2型糖尿病患者的口服治疗基础上随机加用甘精胰岛素或人NPH胰岛素。
Diabetes Care. 2003 Nov;26(11):3080-6. doi: 10.2337/diacare.26.11.3080.