Sakkas L I, Loqueman N, Panayi G S, Myles A B, Welsh K I
Division of Medicine, UMDS, Guy's Hospital, London.
Br J Rheumatol. 1990 Oct;29(5):331-4. doi: 10.1093/rheumatology/29.5.331.
Evidence suggests that polymyalgia rheumatica (PMR) may be an immune-mediated disease. Therefore, the role of HLA class II genes, the switch region of immunoglobin mu and alpha 1 heavy chain as the T-cell receptor (TcR) genes were investigated by Southern blot analysis. The frequency of DR4 specificity was increased in PMR (67.4% versus 30.3%; P = 0.00017). No association was found with the DQA and DQB genes, the switch region of immunoglobulin mu and alpha 1 heavy chain genes, and the TcR alpha, beta and gamma genes. This study suggests that HLA-DR4 is an important susceptibility factor for PMR. Further studies are needed to elucidate the role of Ig and TcR genes.
有证据表明风湿性多肌痛（PMR）可能是一种免疫介导的疾病。因此，通过Southern印迹分析研究了HLA II类基因、免疫球蛋白μ和α1重链的转换区作为T细胞受体（TcR）基因的作用。PMR中DR4特异性的频率增加（67.4%对30.3%；P = 0.00017）。未发现与DQA和DQB基因、免疫球蛋白μ和α1重链基因的转换区以及TcRα、β和γ基因存在关联。本研究表明HLA-DR4是PMR的一个重要易感因素。需要进一步研究以阐明Ig和TcR基因的作用。
