al-Jarallah K F, Buchanan W W, Sastry A, Singal D P
Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Clin Exp Rheumatol. 1993 Sep-Oct;11(5):529-31.
The distribution of HLA-D region antigens was studied in 17 patients with well-documented polymyalgia rheumatica (PMR). HLA-D region antigens were defined by the oligonucleotide typing of polymerase chain reaction (PCR)-amplified genomic DNA. The results demonstrate that the prevalence of DR4 was significantly higher (p < 0.0002; RR = 8.10) in patients (70.6%) compared to normal controls (22.9%), and the frequency of DR1 and/or DR4 in patients (82.4%) was also higher (p < 0.0006; RR = 8.40) than that in normal healthy controls (35.7%). Of the subtypes of DR4,Dw13 was significantly higher (p < 0.002; RR = 9.30) in patients (29.4%) than in normal controls (4.3%). However, these data must still be confirmed by other investigators. The distribution of the remaining DR antigens and of the DQ and DP alleles in patients did not differ significantly from those in controls. The results suggest immunogenetic similarity between PMR and late onset rheumatoid arthritis in elderly populations.
对17例有充分文献记录的风湿性多肌痛（PMR）患者的HLA - D区域抗原分布进行了研究。通过聚合酶链反应（PCR）扩增基因组DNA的寡核苷酸分型来确定HLA - D区域抗原。结果表明，与正常对照组（22.9%）相比，患者中DR4的患病率显著更高（p < 0.0002；RR = 8.10），患者中DR1和/或DR4的频率（82.4%）也高于正常健康对照组（35.7%）（p < 0.0006；RR = 8.40）。在DR4的亚型中，患者中Dw13的比例（29.4%）显著高于正常对照组（4.3%）（p < 0.002；RR = 9.30）。然而，这些数据仍须由其他研究者加以证实。患者中其余DR抗原以及DQ和DP等位基因的分布与对照组相比无显著差异。结果提示在老年人群中PMR与晚发型类风湿关节炎之间存在免疫遗传学相似性。
