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Tyramine antagonizes proctolin-induced contraction of the isolated foregut of the locust Schistocerca gregaria by an interaction with octopamine2 receptors.

作者信息

Banner S E, Wood S J, Osborne R H, Cattell K J

机构信息

Beecham Pharmaceuticals, Medicinal Research Centre, Harlow, Essex, U.K.

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1990;95(2):233-6. doi: 10.1016/0742-8413(90)90110-u.

DOI:10.1016/0742-8413(90)90110-u
PMID:1977552
Abstract
  1. Octopamine (OA) (10(-7)-10(-5) M) relaxed isolated foreguts. Tyramine mimicked the effects of OA but was 64x less potent. 2. Proctolin (10(-8) M to 10(-6) M) induced contraction of isolated foreguts was antagonised non competitively by tyramine. 3. Mianserin (10(-6) M) was a non competitive antagonist of relaxation caused by tyramine but was without effect on proctolin induced contraction. 4. Caffeine (1 microM and 2 microM) caused non competitive inhibition of proctolin-induced tissue contraction. 5. It is concluded that tyramine antagonises proctolin-induced contraction of the foregut by activating an adenylate cyclase-linked OA2 receptor.
摘要

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