Voronina T A, Garibova T L, Khromova I V, Kuznetsova E A, Smirnov L D
Farmakol Toksikol. 1990 Jul-Aug;53(4):13-6.
The psychopharmacological activity of a new compound--ONK-10--N-5(hydroxynicotinoyl)-L-glutamic acid was studied. It was shown in experiments on mice and rats that the compound possesses the pronounced antiamnestic and antihypoxic effects, does not disturb the conditioned reflex activity and the orientation behavior, has no anxiolytic activity and anticonvulsant properties, causes no disorder of movement coordination, is low toxic. ONK-10 is superior by its antiamnestic and antihypoxic effects to piracetam, meclophenoxat, demanol aceglumate and is not inferior to aniracetam.
对一种新化合物——ONK - 10（N - 5（羟基烟酰基）- L - 谷氨酸）的精神药理学活性进行了研究。在对小鼠和大鼠的实验中表明，该化合物具有明显的抗遗忘和抗缺氧作用，不干扰条件反射活动和定向行为，无抗焦虑活性和抗惊厥特性，不引起运动协调障碍，毒性低。ONK - 10在抗遗忘和抗缺氧作用方面优于吡拉西坦、甲氯芬酯、地阿诺醋谷胺，且不逊于阿尼西坦。
