Inozemtsev A N, Garibova T L, Khromova I V, Alvarez R, Voronina T A, Tushmalova N A
Eksp Klin Farmakol. 1993 Mar-Apr;56(2):6-8.
We studied effects of a new drug with nootropic action nooglutil (N-(5-hydroxynicotinoil)-L-glutaminic acid, OHK-10) on initial stages of different forms of operant behaviour in rats, namely avoidance learning in Shuttle box, in Skinner box and on T-maze reflex with water reward. Comparing dates resulted from these three methods permitted evaluation of effects of the drugs on learning. Both drugs had no effects on avoidance response in shuttle box and T-maze reflex with water reward. Nooglutil enhanced escape and avoidance responses meanwhile piracetam improved only escape response.
我们研究了一种具有促智作用的新药脑复新（N-(5-羟基烟酰基)-L-谷氨酸，OHK-10）对大鼠不同形式操作性行为初始阶段的影响，即在穿梭箱、斯金纳箱中的回避学习以及水奖励T迷宫反射。比较这三种方法得到的数据有助于评估药物对学习的影响。两种药物对穿梭箱中的回避反应和水奖励T迷宫反射均无影响。脑复新增强了逃避和回避反应，而吡拉西坦仅改善了逃避反应。
