Wunderlich Arthur Peter, Schönfeldt-Lecuona Carlos, Wolf Robert Christian, Dorn Kristina, Bachor Edgar, Freund Wolfgang
Clinic for Diagnostic and Interventional Radiology, University Clinic Ulm, Ulm, Germany.
Audiol Neurootol. 2010;15(3):137-48. doi: 10.1159/000241094. Epub 2009 Sep 24.
Chronic subjective tinnitus has been associated with aberrant activation of cortical areas involved in the perception of auditory information. This leads to the hypothesis that neural correlates of altered auditory perception may be found in tinnitus patients using functional magnetic resonance imaging. To study brain activation patterns due to acoustic stimulation in a pitch discrimination task, 6 tinnitus patients and 6 age-matched controls were investigated. Tones were presented binaurally at 5 beeps/s with three different frequencies in a block design. Using Statistical Parametrical Mapping, we found activation of secondary auditory areas in both groups. Furthermore, controls showed activation of the right-hemispheric anterior insula, whereas the middle frontal gyrus, putamen and left-hemispheric insula were activated in tinnitus patients. In the between-group analysis, activation of the caudate nucleus, superior frontal gyrus (Brodmann area 8) and cingular cortex was more pronounced in patients than in controls suggesting the perception of auditory inputs in a more emotional context in our patient group compared to controls.
慢性主观性耳鸣与参与听觉信息感知的皮层区域异常激活有关。这引发了一种假设，即使用功能磁共振成像可能会在耳鸣患者中发现听觉感知改变的神经关联。为了研究在音高辨别任务中声学刺激引起的大脑激活模式，对6名耳鸣患者和6名年龄匹配的对照组进行了调查。采用组块设计，以每秒5次蜂鸣声的频率双耳呈现三种不同频率的音调。使用统计参数映射，我们发现两组均激活了二级听觉区域。此外，对照组显示右半球前岛叶激活，而耳鸣患者激活了额中回、壳核和左半球岛叶。在组间分析中，与对照组相比，患者的尾状核、额上回（布罗德曼8区）和扣带回皮层的激活更为明显，这表明与对照组相比，我们的患者组在更情绪化的背景下感知听觉输入。
