中耳积液动物模型中耳蜗反应的变化。
Change in cochlear response in an animal model of otitis media with effusion.
作者信息
Dai Chenkai, Gan Rong Z
机构信息
University of Oklahoma, Norman, OK, USA.
出版信息
Audiol Neurootol. 2010;15(3):155-67. doi: 10.1159/000241096. Epub 2009 Sep 24.
Our previous studies confirm that middle ear mobility is reduced in the presence of otitis media with effusion (OME). Variations in middle ear function may result in changes in cochlear response in OME ears. With the long-term goal of evaluating cochlear function in OME ears, the aim of this study was to measure the displacement of the basilar membrane (BM) in guinea pig ears with OME. Vibrations of the BM at the apex and basal turn were measured in an in vitro preparation extracted 3 and 14 days after injection of lipopolysaccharide in the middle ear of guinea pigs. The results show that the displacement sensitivity of the BM at the apex and the basal turn to sound pressure in the ear canal was reduced up to 25 dB at their characteristic frequencies, respectively. Cochlear gain with respect to umbo movement was also changed in ears with OME in both groups. This study provides data for analysis of the change of BM vibration in a guinea pig OME model.
我们之前的研究证实，在存在中耳积液（OME）的情况下，中耳的活动度会降低。中耳功能的变化可能导致OME耳的耳蜗反应发生改变。为了实现评估OME耳耳蜗功能的长期目标，本研究的目的是测量患有OME的豚鼠耳中基底膜（BM）的位移。在豚鼠中耳注射脂多糖3天和14天后提取的体外制剂中，测量了BM在顶转和底转处的振动。结果表明，在其特征频率下，BM在顶转和底转处对耳道声压的位移敏感度分别降低了25 dB。两组患有OME的耳朵中，相对于鼓膜脐部运动的耳蜗增益也发生了变化。本研究为分析豚鼠OME模型中BM振动的变化提供了数据。
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