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与痴呆相关的前角细胞变性和布尼纳型包涵体。

Anterior horn cell degeneration and Bunina-type inclusions associated with dementia.

作者信息

Hart M N, Cancilla P A, Frommes S, Hirano A

出版信息

Acta Neuropathol. 1977 Jun 15;38(3):225-8. doi: 10.1007/BF00688069.

DOI:10.1007/BF00688069
PMID:197771
Abstract

The ultrastructural features of Bunina type inclusions in the anterior horn cells of a patient dying of amyotrophic lateral sclerosis with dementia appear unique. The Bunina-type inclusions are electron dense aggregates containing, and surrounded by organelle-like membranes. These inclusions appear to be a special type of autophagic vacuole, possibly arising from altered mitochondria.

摘要

在死于肌萎缩侧索硬化症合并痴呆症患者的前角细胞中,布尼纳型包涵体的超微结构特征显得独特。布尼纳型包涵体是电子致密聚集体,含有类细胞器膜并被其包围。这些包涵体似乎是一种特殊类型的自噬泡,可能源于线粒体的改变。

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Pathoanatomic changes in amyotrophic lateral sclerosis on Guam. Special reference to the occurrence of neurofibrillary changes.关岛肌萎缩侧索硬化症的病理解剖学变化。特别提及神经原纤维变化的发生情况。
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[On intracellular inclusions in familial amyotrophic lateral sclerosis].[关于家族性肌萎缩侧索硬化症中的细胞内包涵体]
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Cytoplasmic components in hepatic cell lysosomes.肝细胞溶酶体中的细胞质成分。
上运动神经元疾病:原发性侧索硬化症、上运动神经元为主型肌萎缩侧索硬化症和遗传性痉挛性截瘫。
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Oxaloacetate treatment preserves motor function in SOD1 mice and normalizes select neuroinflammation-related parameters in the spinal cord.草酰乙酸处理可保护 SOD1 小鼠的运动功能,并使脊髓中与神经炎症相关的特定参数正常化。
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