Mohan Uthara R, Danon Saar, Levi Daniel, Connolly Dana, Moore John W
Rady Children's Hospital and UCSD, San Diego, California 92123, USA.
JACC Cardiovasc Interv. 2009 Sep;2(9):877-83. doi: 10.1016/j.jcin.2009.07.002.
Our aim was to determine key characteristics of stents commonly implanted in the aorta through bench testing and to describe our technique and acute results in patients weighing <30 kg.
Despite the increasing use of stents for interventional treatment for coarctation of the aorta (CoA) in larger patients, use of large stents is controversial in small children.
Methods included bench testing of large stents, and retrospective review of all patients over 1 year of age who had stent implantation for treatment of CoA. Patients were divided into 2 groups based on weight. Paired comparisons were made before and after stent implantation, and group outcomes were compared.
Sixty patients comprised the entire sample, with 22 patients assigned to group I (<30 kg) and 38 patients assigned to group II (>or=30 kg). The mean minimum diameters of the CoA (group I 5.0 to 10.7 mm; group II 8.0 to 15.0 mm) and the ratio of the coarctation diameter to the descending aorta diameter measured at the level of the diaphragm (CoA/DAo ratio) (group I 0.4 to 0.93; group II 0.46 to 0.94) increased significantly in both groups (all p < 0.05). The mean systolic gradient decreased significantly in both groups (group I 23.0 to 2.0 mm Hg; group II 24.0 to 2.8 mm Hg; both p = 0.001). No difference was found between the groups in the CoA/DAo ratio, residual systolic gradients, or the decrease in systolic gradient after stent implantation. There were no significant complications in patients under 30 kg.
As in larger patients, use of large stents for treatment of CoA in small children is effective and safe in the short term. In these patients, stent redilations will be required, and follow-up is ongoing.
我们的目标是通过台架测试确定常用于主动脉植入的支架的关键特性,并描述我们在体重<30kg患者中的技术和急性结果。
尽管在较大患者中使用支架介入治疗主动脉缩窄(CoA)的情况越来越多,但在幼儿中使用大型支架仍存在争议。
方法包括大型支架的台架测试,以及对所有1岁以上接受支架植入治疗CoA的患者进行回顾性研究。根据体重将患者分为2组。在支架植入前后进行配对比较,并比较组间结果。
60例患者构成整个样本,22例患者被分配到I组(<30kg),38例患者被分配到II组(≥30kg)。两组中CoA的平均最小直径(I组5.0至10.7mm;II组8.0至15.0mm)以及在膈肌水平测量的缩窄直径与降主动脉直径之比(CoA/DAo比值)(I组0.4至0.93;II组0.46至0.94)均显著增加(所有p<0.05)。两组的平均收缩压梯度均显著降低(I组23.0至2.0mmHg;II组24.0至2.8mmHg;两者p=0.001)。两组在CoA/DAo比值、残余收缩压梯度或支架植入后收缩压梯度的降低方面没有差异。30kg以下患者无明显并发症。
与较大患者一样,在幼儿中使用大型支架治疗CoA在短期内是有效且安全的。在这些患者中,需要进行支架再扩张,并且随访正在进行中。