Department of Internal Medicine, Section of Rheumatology, Tampere UniversityHospital, Tampere, Finland.
Rheumatology (Oxford). 2009 Dec;48(12):1553-6. doi: 10.1093/rheumatology/kep288. Epub 2009 Sep 24.
There is ample evidence demonstrating that accelerated atherosclerosis prevails in autoimmune rheumatic diseases, particularly in SLE, and that the risk is due not only to traditional cardiovascular risk factors but also to the disease itself. ANAs are a hallmark of SLE and are known even to antedate the development of SLE. Our aim was to investigate whether positive ANAs in young adults are associated with risk factors for atherosclerosis or subclinical markers of atherosclerosis.
ANAs were examined by IIF using HEp-2 cells as substrate in 2278 participants in the Cardiovascular Risk in Young Finns Study for whom detailed data on cardiovascular risk factors and markers of subclinical atherosclerosis (including brachial flow-mediated dilatation, carotid compliance and carotid intima-media thickness) were available.
In multivariate analyses, adjusted for age, BMI, serum concentrations of CRP, triglycerides, high-density lipoprotein and low-density lipoprotein cholesterol, blood pressure and smoking habits, ANA positivity (titre > 160) was inversely associated (beta = -0.145; P = 0.034) with carotid compliance in women.
Our results indicate that ANA positivity is associated with decreased carotid elasticity in women, suggesting that mechanisms resulting in ANA production may be involved in the development of early atherosclerosis.
有大量证据表明，自身免疫性风湿病中普遍存在动脉粥样硬化加速，尤其是在系统性红斑狼疮（SLE）中，并且这种风险不仅归因于传统心血管危险因素，还归因于疾病本身。抗核抗体（ANA）是 SLE 的特征性标志物，甚至在 SLE 发病前就已出现。我们的目的是研究年轻成年人中阳性 ANA 是否与动脉粥样硬化的危险因素或亚临床动脉粥样硬化标志物相关。
在心血管风险年轻芬兰人研究中，对 2278 名参与者进行了间接免疫荧光法（IIF）检查，使用 Hep-2 细胞作为底物，这些参与者有详细的心血管危险因素和亚临床动脉粥样硬化标志物（包括肱动脉血流介导的舒张、颈动脉顺应性和颈动脉内膜中层厚度）的数据。
在多变量分析中，调整年龄、BMI、CRP、甘油三酯、高密度脂蛋白和低密度脂蛋白胆固醇、血压和吸烟习惯后，ANA 阳性（滴度>160）与女性颈动脉顺应性呈负相关（β=-0.145；P=0.034）。
我们的结果表明，ANA 阳性与女性颈动脉弹性降低有关，提示导致 ANA 产生的机制可能参与了早期动脉粥样硬化的发生。
