Kies Merrill S
Department of Thoracic/Head and Neck Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.
J Natl Compr Canc Netw. 2004 Sep;2 Suppl 2:S52-9.
The combination of chemotherapy and radiation is increasingly considered a standard treatment for patients with locally advanced squamous cell carcinoma of the head and neck. Tumor control is often obtained, but toxicity is increased with combined modality treatment. The efficacy of platinum-based chemotherapy regimens has been well documented. Carboplatin offers a favorable toxicity profile compared with cisplatin. Carboplatin-based regimens have been evaluated for both locally advanced and metastatic or recurrent disease. Phase III assessment of carboplatin plus paclitaxel is warranted, alone or in combination with novel targeted therapies. Novel agents that target the epidermal growth factor receptor have shown particular promise in the management of squamous cell carcinoma of the head and neck.
化疗与放疗相结合越来越被视为局部晚期头颈部鳞状细胞癌患者的标准治疗方法。通常能实现肿瘤控制，但联合治疗会增加毒性。铂类化疗方案的疗效已有充分记录。与顺铂相比，卡铂具有更好的毒性特征。基于卡铂的方案已针对局部晚期以及转移性或复发性疾病进行了评估。有必要对卡铂联合紫杉醇进行III期评估，单独使用或与新型靶向疗法联合使用。靶向表皮生长因子受体的新型药物在头颈部鳞状细胞癌的治疗中显示出特别的前景。
