Tyczkowska-Sieroń Ewa, Bartoszko-Tyczkowska Anna, Gaszyński Wojciech
Zakład Biologii Srodowiskowej, Katedra Nauk Podstawowych i Przedklinicznych, UM w Łodzi.
Med Dosw Mikrobiol. 2009;61(2):159-65.
In this paper, relations between the number of nosocomial infections caused by multi-drug resistant pathogens and antibiotic-therapy were investigated. It was found that the number of MRSA infections is directly proportional to the amount of CAZ (ceftazidime) used in the therapy. It was also stated that CAZ, Amc (amoxicillin-clavulan acid) and IPM (imipenem) are strong inductors of ESBL. A good correlation between the number of infections caused by ESBL(+) strains and the total consumption of these antibiotics was found. A growing number of infections generated by Ps. aeruginosa and Acinetobacter spp. strains resistant to carbapenems as a result of IPM therapy is also an anxiety-provoking fact. In this case, the changes in the number of isolated IPM-R streins occur only after approx. half an year from the changes in the IPM consumption.
本文研究了多重耐药病原体引起的医院感染数量与抗生素治疗之间的关系。发现耐甲氧西林金黄色葡萄球菌（MRSA）感染数量与治疗中使用的头孢他啶（CAZ）量成正比。还指出，CAZ、阿莫西林-克拉维酸（Amc）和亚胺培南（IPM）是超广谱β-内酰胺酶（ESBL）的强诱导剂。发现ESBL（+）菌株引起的感染数量与这些抗生素的总消耗量之间存在良好的相关性。由于IPM治疗导致对碳青霉烯类耐药的铜绿假单胞菌和不动杆菌属菌株引起的感染数量不断增加，这也是一个令人担忧的事实。在这种情况下，IPM耐药菌株分离数量的变化仅在IPM消耗量变化约半年后出现。
