肾移植受者中对人巨细胞病毒感染作出反应的γδ T细胞和CD8(+)αβ T细胞的共同特征。
Common features of gammadelta T cells and CD8(+) alphabeta T cells responding to human cytomegalovirus infection in kidney transplant recipients.
作者信息
Couzi Lionel, Pitard Vincent, Netzer Sonia, Garrigue Isabelle, Lafon Marie-Edith, Moreau Jean-François, Taupin Jean-Luc, Merville Pierre, Déchanet-Merville Julie
机构信息
Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France.
出版信息
J Infect Dis. 2009 Nov 1;200(9):1415-24. doi: 10.1086/644509.
BACKGROUND
Kidney transplant recipients infected with cytomegalovirus (CMV) undergo a persistent gammadelta T cell expansion in their peripheral blood. The anti-CMV function of these cells was previously demonstrated by their ability to kill CMV-infected cells in vitro.
METHODS
To gain insight into the role of gammadelta T cells within the antiviral immune network, we compared the expansion kinetics of these T cells with that of CMV pp65-specific CD8(+) alphabeta T cells in the peripheral blood of twenty-one kidney transplant recipients.
RESULTS
Both the percentage and the absolute number of pp65-specific CD8(+) T cells and gammadelta T cells showed a concomitant increase and persistence in most of the kidney transplant recipients with CMV infection. Both cell subsets exhibited an effector/memory phenotype (CD28(-), CD27(-), and CD45RA(+)) that predominated for the entire follow-up period.
CONCLUSIONS
In conclusion, CMV-specific CD8(+) alphabeta T cells and gammadelta T cells share common expansion kinetics and a common effector phenotype, suggesting that these cell types act similarly in response to CMV infection.
背景
感染巨细胞病毒（CMV）的肾移植受者外周血中γδT细胞持续扩增。这些细胞的抗CMV功能先前已通过其在体外杀伤CMV感染细胞的能力得到证实。
方法
为深入了解γδT细胞在抗病毒免疫网络中的作用，我们比较了21例肾移植受者外周血中这些T细胞与CMV pp65特异性CD8(+)αβT细胞的扩增动力学。
结果
在大多数感染CMV的肾移植受者中，pp65特异性CD8(+) T细胞和γδT细胞的百分比及绝对数量均呈现同步增加且持续存在的现象。两个细胞亚群均表现出效应/记忆表型（CD28(-)、CD27(-)和CD45RA(+)），且在整个随访期间占主导地位。
结论
总之，CMV特异性CD8(+)αβT细胞和γδT细胞具有共同的扩增动力学和共同的效应表型，表明这些细胞类型在对CMV感染的反应中作用相似。
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