Ali Syed A, Benitez Jorge A
Morehouse School of Medicine Department of Microbiology, SW Atlanta, Georgia 30310, USA.
Microbiol Immunol. 2009 Oct;53(10):582-6. doi: 10.1111/j.1348-0421.2009.00161.x.
The formation of biofilm communities enhances the persistence of Vibrio cholerae in aquatic environments. Biofilm production is repressed by the quorum-sensing regulator HapR in response to the accumulation of CAI-1 and AI-2. CAI-1 is the strongest input signal activating HapR, whereas the role of AI-2 remains ill-defined. In the present study, we show that a V. cholerae luxS (AI-2-defective) mutant made increased biofilm. Interestingly, cells in the biofilm were more responsive to AI-2 deficiency than cells from the planktonic population.
生物膜群落的形成增强了霍乱弧菌在水生环境中的持久性。群体感应调节因子HapR会响应CAI-1和AI-2的积累而抑制生物膜的产生。CAI-1是激活HapR的最强输入信号，而AI-2的作用仍不明确。在本研究中，我们发现霍乱弧菌luxS（AI-2缺陷型）突变体形成的生物膜增多。有趣的是，生物膜中的细胞比浮游群体中的细胞对AI-2缺陷更敏感。
