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植物 microRNAs 对盐度和干旱响应的转录后基因调控。

Post-transcriptional gene regulation of salinity and drought responses by plant microRNAs.

机构信息

Dept. Biología Molecular de Plantas, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca Mor., Mexico.

出版信息

Plant Cell Environ. 2010 Apr;33(4):481-9. doi: 10.1111/j.1365-3040.2009.02048.x. Epub 2009 Sep 23.

Abstract

In the past few years, factors involved in abscisic acid signalling have been isolated and recognized as elements related to RNA metabolism, suggesting that post-transcriptional regulation of gene expression is required for abiotic stress responses. Some of these factors can be linked to the biogenesis of microRNAs (miRNAs), small RNA molecules that are important regulators of gene expression at the posttranscriptional level by repressing mRNA expression. Here, we review the role of miRNAs in stress responses, highlighting recent advances in elucidating the role of individual miRNAs and efforts to identify stress-responsive miRNAs at a genome-wide level in different model plants. Complete understanding of miRNA action depends on the identification of its target transcripts, and recent developments in miRNA research indicate that they will be uncovered in the near future.

摘要

在过去的几年中,已分离出与脱落酸信号转导相关的因子,并将其鉴定为与 RNA 代谢相关的元件,这表明非生物胁迫反应需要基因表达的转录后调控。其中一些因子可以与 microRNAs(miRNAs)的生物发生相关联,miRNAs 是一类重要的小 RNA 分子,通过抑制 mRNA 的表达,在转录后水平上对基因表达进行重要调控。在这里,我们综述了 miRNAs 在胁迫反应中的作用,强调了阐明单个 miRNAs 作用以及在不同模式植物中从全基因组水平鉴定胁迫响应 miRNAs 的最新进展。对 miRNA 作用的完整理解取决于其靶标转录本的鉴定,miRNA 研究的最新进展表明,它们将在不久的将来被揭示。

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