Swelam Wael M, Cheng Jun, Ida-Yonemochi Hiroko, Maruyama Satoshi, Saku Takashi
Division of Oral Pathology, Department of Biomedical Dental Sciences, King Faisal University, Saudi Arabia.
Cancer Genet Cytogenet. 2009 Oct 15;194(2):75-81. doi: 10.1016/j.cancergencyto.2009.05.003.
Solitary fibrous tumor (SFT) is an uncommon spindle-cell neoplasm of mesenchymal origin. Because the pathogenetic background of SFT is still controversial, cytogenetic analysis could help in tumor diagnosis and prognosis. In this study, cultured SFT cells from a lower lip lesion that presented characteristic immunopositivity for CD34, vimentin, CD99, and BCL2 showed a unique cytogenetic finding: 46,XX,inv(2)(p21q35),t(3;12)(q25;q15). To our knowledge, this is the third report of cytogenetic result of a case involving the oral cavity. The SFT cells in culture that maintained their immunohistochemical expression of diagnostic molecules, showed unique chromosomal changes previously unreported when compared with already documented ones. Our data suggest that the complicated pathogenetic nature of SFT is possibly tumor- or organ-related.
