Knösel T, Schulz B, Katenkamp K, Katenkamp D, Petersen I
Institut für Pathologie, Friedrich-Schiller-Universität, Ziegelmühlenweg 1, 07743, Jena, Deutschland.
Pathologe. 2010 Mar;31(2):123-8. doi: 10.1007/s00292-009-1253-x.
Soft-tissue tumors with haemangiopericytoma (HPC)-like growth patterns can now be divided into three categories: (1) The solitary fibrous tumour (SFT) group with its variants; (2) lesions showing clear evidence of myoid/pericytic differentiation and corresponding to "true" HPCs (myopericytoma/glomangiopericytoma and a subset of sinonasal HPCs); (3) neoplasms that occasionally display HPC-like features (e.g. synovial sarcoma). In this study 268 intrathoracic and extrathoracic SFTs from the German consultation and reference center of soft tissue tumors in Jena were evaluated and analyzed immunohistochemically with antibodies CD34, Bcl-2, CD99, SMA, S100, PanCK and Ki-67. Furthermore, SFTs were categorized into the newly proposed SFT designation: Fibrous variant, cellular variant (more than 90% hypercellularity), fat-forming variant, giant cell-rich variant and malignant SFTs. This article should provide insights into the diagnosis of this entity with emphasis on the new international standard.
具有血管外皮细胞瘤（HPC）样生长模式的软组织肿瘤目前可分为三类：（1）孤立性纤维性肿瘤（SFT）及其变异型；（2）显示出明确的肌样/周细胞分化证据且对应于“真性”HPC的病变（肌周细胞瘤/血管球外皮细胞瘤以及鼻窦HPC的一个子集）；（3）偶尔表现出HPC样特征的肿瘤（如滑膜肉瘤）。在本研究中，对来自耶拿德国软组织肿瘤咨询与参考中心的268例胸内和胸外SFT进行了评估，并使用抗CD34、Bcl-2、CD99、平滑肌肌动蛋白（SMA）、S100、细胞角蛋白（PanCK）和Ki-67抗体进行了免疫组化分析。此外，SFT被归类为新提出的SFT命名：纤维变异型、细胞变异型（细胞增多超过90%）、脂肪形成变异型、富含巨细胞变异型和恶性SFT。本文旨在强调新的国际标准，为该实体的诊断提供见解。
