枣（Zizyphus lotus (L.) Desf.）提取物对离体大鼠十二指肠的抗痉挛作用。

Anti-spasmodic effects of Zizyphus lotus (L.) Desf. extracts on isolated rat duodenum.

机构信息

Laboratory of Pharmacology, Faculty of Pharmacy, Monastir 5000, Tunisia.

出版信息

J Ethnopharmacol. 2009 Dec 10;126(3):571-3. doi: 10.1016/j.jep.2009.09.022. Epub 2009 Sep 23.

DOI:10.1016/j.jep.2009.09.022

PMID:19781617

Abstract

AIM OF THE STUDY

The present study deals with the anti-spasmodic activity of the aqueous and the methanolic extracts of the leaves and the root barks of Zizyphus lotus (L.) Desf. on male rats.

MATERIALS AND METHODS

This activity was assessed on contractions of isolated rat duodenum, induced by acetylcholine, KCl, and BaCl(2) and compared with the effect of atropine and papaverine.

RESULTS

Both extracts of leaves and root barks caused significant relaxation of spontaneous contractions and produced a concentration-dependent inhibition (P<0.01-0.001) of contraction induced by spasmogenic agents.

CONCLUSION

These results indicate that Zizyphus lotus extracts contain anti-spasmodic constituents mediating their effect through cholinergic receptors and blockade Ca(2+) influx. This could explain the traditional use of Zizyphus lotus in the treatment of the intestinal diseases.

摘要