Institute for Genetics, Centre for Molecular Medicine (CMMC), Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, D-50674 Cologne, Germany.
Res Microbiol. 2009 Nov;160(9):711-7. doi: 10.1016/j.resmic.2009.09.005. Epub 2009 Sep 22.
FtsH/AAA proteases comprise a distinct family of membrane-bound, ATP-dependent proteases present in eubacteria and eukaryotic cells, where they are confined to mitochondria and chloroplasts. Here, we will summarize versatile functions of AAA proteases within mitochondria, which ensure mitochondrial integrity and cell survival, acting both as quality control and processing enzymes.
FtsH/AAA 蛋白酶属于膜结合的 ATP 依赖蛋白酶家族，存在于真细菌和真核细胞中，它们局限在线粒体和叶绿体中。在这里，我们将总结 AAA 蛋白酶在线粒体中的多种功能，这些功能确保了线粒体的完整性和细胞的存活，它们既是质量控制酶，也是加工酶。
