Vijayaraghavan K, Radhaiah G, Prakasam B S, Sarma K V, Reddy V
National Institute of Nutrition, Hyderabad, India.
Lancet. 1990 Dec 1;336(8727):1342-5. doi: 10.1016/0140-6736(90)92895-o.
The effect of vitamin A supplementation on preschool child morbidity and mortality was assessed in a prospective double-blind placebo-controlled study around Hyderabad, India. Every six months 200,000 IU vitamin A was given to 7691 children (treatment group) whereas 8084 children received a placebo (control group). Morbidity and mortality data were collected every three months. Risk of respiratory infection was higher in children with mild xerophthalmia than in children with normal eyes. Vitamin A supplementation had no effect on morbidity status. Mortality rates were similar in the two groups; it was highest in children who did not receive either vitamin A or placebo. The findings suggest that vitamin A supplementation alone may not reduce child mortality.
在印度海得拉巴市周边进行的一项前瞻性双盲安慰剂对照研究中，评估了补充维生素A对学龄前儿童发病率和死亡率的影响。每六个月给7691名儿童（治疗组）服用200,000国际单位的维生素A，而8084名儿童接受安慰剂（对照组）。每三个月收集发病率和死亡率数据。轻度干眼症儿童发生呼吸道感染的风险高于眼睛正常的儿童。补充维生素A对发病状况没有影响。两组的死亡率相似；未接受维生素A或安慰剂的儿童死亡率最高。研究结果表明，单独补充维生素A可能无法降低儿童死亡率。
