Harvard Stem Cell Institute, Department of Stem Cell and Regeneration Biology, Harvard University, Cambridge, MA 02138, USA.
Curr Opin Cell Biol. 2009 Dec;21(6):727-32. doi: 10.1016/j.ceb.2009.08.006. Epub 2009 Sep 24.
Insulin-producing beta cells are lost or insufficient in diabetic patients, presenting the medical challenge for new beta cells. Currently, there are three strategies that offer promise. One involves the generation of beta cells de novo by directing the differentiation of either embryonic stem cells or induced pluripotent cells to the beta cell lineage. The second is based on the conversion of another terminally differentiated cell to beta cells in a process called reprogramming. The third approach is to promote the replication of existing beta cells either in vivo or in vitro. Significant progress is evident for each strategy, but it remains unclear which approach will ultimately prove successful.
在糖尿病患者中，产生胰岛素的β细胞缺失或不足，这对新β细胞的产生提出了医学挑战。目前，有三种策略具有应用前景。一种方法是通过诱导胚胎干细胞或诱导多能细胞向β细胞谱系分化来从头产生β细胞。第二种方法基于将另一种终末分化细胞在称为重编程的过程中转分化为β细胞。第三种方法是促进体内或体外现有β细胞的复制。每种策略都取得了显著进展，但哪种方法最终会成功仍不清楚。
