Zheng Jie, Manduchi Elisabetta, Stoeckert Christian J
Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA.
bioRxiv. 2025 Aug 25:2025.08.18.670933. doi: 10.1101/2025.08.18.670933.
The development process for the beta cell genomics application ontology (BCGO) is described. This process should be generally applicable and consists of integration of a subset of reference ontologies. A key element is use of the Ontology for Biomedical Investigation (OBI) as an ontology framework. Another element is enriching ontologies using existing patterns when needed. The ontology is validated in three aspects based on our needs including data annotation, queries and automated classification. The BCGO is available on: http://purl.obolibrary.org/obo/bcgo.owl.
本文描述了β细胞基因组学应用本体（BCGO）的开发过程。该过程应具有普遍适用性，包括整合参考本体的一个子集。一个关键要素是使用生物医学调查本体（OBI）作为本体框架。另一个要素是在需要时使用现有模式丰富本体。基于我们在数据注释、查询和自动分类方面的需求，从三个方面对该本体进行了验证。BCGO可在以下网址获取：http://purl.obolibrary.org/obo/bcgo.owl 。
