Lamb J R, Young D B
Department of Immunology, Royal Postgraduate Medical School, Hammersmith Hospital, London, U.K.
Mol Biol Med. 1990 Aug;7(4):311-21.
Exposure of any living cell to a change in environmental conditions such as increased growth temperature results in the induction of stress, or "heat shock", proteins. Proteins identified in such experiments have subsequently been shown to be ubiquitous components of all cells and to perform essential functions during normal cell growth in addition to their role during stress. It has recently been recognized that members of stress protein families play an important role in the immune response to a wide variety of infections, and the highly conserved nature of such proteins has led to the suggestion that they may also be immune targets in autoreactive responses. In this article we review the role of stress proteins in the immune response to infection and discuss the evidence which suggests that lymphocytes recognizing conserved determinants on such antigens may be associated with autoimmune diseases.
任何活细胞暴露于环境条件变化（如生长温度升高）都会导致应激或“热休克”蛋白的诱导产生。在这类实验中鉴定出的蛋白质随后被证明是所有细胞的普遍组成成分，并且除了在应激期间发挥作用外，还在正常细胞生长过程中执行重要功能。最近人们认识到，应激蛋白家族成员在对多种感染的免疫反应中发挥重要作用，而且这类蛋白质的高度保守性促使人们提出，它们可能也是自身反应性应答中的免疫靶点。在本文中，我们综述了应激蛋白在感染免疫反应中的作用，并讨论了表明识别此类抗原上保守决定簇的淋巴细胞可能与自身免疫性疾病相关的证据。
