中国西北汉族人群六个微型短串联重复序列（miniSTR）基因座的等位基因频率。
Allele frequencies for six miniSTR loci of Northwestern Chinese Han populations.
作者信息
Bai Xue, Cong Bin, Li Shujin, Guo Xia, Li Xia, He Lujun
机构信息
Department of Forensic Medicine, HeBei Medical University, No. 361 Zhong Shan east Road, Shijiazhuang, HeBei 050017, PR China.
出版信息
J Forensic Leg Med. 2009 Nov;16(8):469-71. doi: 10.1016/j.jflm.2009.05.004. Epub 2009 Jun 25.
MiniSTR loci has demonstrated to be an effective approach to recover genetic information from degraded sample, due to the improved PCR efficiency of their reduced PCR product sizes. Allele frequencies and forensic parameters for the six miniSTR loci D10S1248, D2S441, D1S1677, D9S1122, D10S1435 and D17S1301 were investigated in 154 Northwestern Chinese Han populations. All loci showed a moderate degree of polymorphism with observed heterozygosity >0.6 and did not show departures from Hardy-Weinberg equilibrium for Northwestern Chinese Han populations. The accumulated powers of discrimination for the six loci were 0.999998.
由于MiniSTR基因座的PCR产物尺寸减小提高了PCR效率，已证明它是从降解样本中恢复遗传信息的有效方法。对154名中国西北汉族人群的六个MiniSTR基因座D10S1248、D2S441、D1S1677、D9S1122、D10S1435和D17S1301的等位基因频率和法医学参数进行了研究。所有基因座均表现出中等程度的多态性，观察到的杂合度>0.6，并且在中国西北汉族人群中未显示出偏离哈迪-温伯格平衡的情况。这六个基因座的累积鉴别力为0.999998。
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