INTOX Private Limited, Pune, MS 412 108, India.
J Inorg Biochem. 2009 Dec;103(12):1748-54. doi: 10.1016/j.jinorgbio.2009.07.014. Epub 2009 Jul 28.
The objective of this study was to evaluate the effects of a novel oxygen-coordinated niacin-bound chromium(III) complex (NBC) on the reproductive systems of male and female rats, the postnatal maturation and reproductive capacity of their offspring, and possible cumulative effects through multiple generations. Sprague-Dawley rats were maintained on feed containing NBC at dose levels of 0, 4, 15, or 60ppm for 10weeks prior to mating, during mating, and, for females through gestation and lactation, across two generations. For the parents (F(0) and F(1)) and the offspring (F(1) and F(2a)), reproductive parameters such as fertility and mating, gestation, parturition, litters, lactation, sexual maturity and development of offspring were assessed. Results from the current study indicated that dietary exposure of NBC to parental male and female rats of both (F(0) and F(1)) the generations during the premating and mating periods, for both sexes, and during gestation and lactation in case of female rats, did not cause any significant incidence of mortality or abnormal clinical signs. Compared to respective controls, NBC exposure did not affect reproductive performance as evaluated by sexual maturity, fertility and mating, gestation, parturition, litter properties, lactation and development of the offspring. Based on the findings of this study, the parental as well as the offspring no-observed-adverse-effect level for NBC was determined to be greater than 60ppm in diet or equivalent to 7.80 and 8.31mg/kg body weight/day in male and female rats, respectively.
本研究旨在评估新型氧配位烟酰胺铬(III)配合物（NBC）对雄性和雌性大鼠生殖系统的影响、其后代的出生后成熟和生殖能力，以及通过多代可能产生的累积效应。在交配前、交配期间以及雌性大鼠在妊娠和哺乳期，Sprague-Dawley 大鼠以 0、4、15 或 60ppm 的 NBC 饲料饲养 10 周。对于亲代（F(0)和 F(1)）和子代（F(1)和 F(2a)），评估了生育能力和交配、妊娠、分娩、窝产仔数、哺乳期、性成熟和后代发育等生殖参数。本研究结果表明，NBC 暴露于亲代雌雄大鼠（F(0)和 F(1)）在交配前和交配期间，以及雌性大鼠在妊娠和哺乳期，不会导致任何明显的死亡率或异常临床症状。与各自的对照组相比，NBC 暴露不会影响生殖性能，如性成熟、生育能力和交配、妊娠、分娩、窝产仔数、哺乳期和后代发育。基于本研究的结果，确定 NBC 的亲代和子代无观察到不良效应水平大于饮食中的 60ppm，或相当于雄性和雌性大鼠分别为 7.80 和 8.31mg/kg 体重/天。
