Jessberger Sebastian, Gage Fred H, Eisch Amelia J, Lagace Diane C
Institute of Cell Biology, Department of Biology, ETH Zurich, Schafmattstrasse 18, 8093 Zurich, Switzerland.
Trends Neurosci. 2009 Nov;32(11):575-82. doi: 10.1016/j.tins.2009.07.002. Epub 2009 Sep 24.
Cyclin-dependent kinase 5 (Cdk5) has been implicated in the migration, maturation and survival of neurons born during embryonic development. New evidence suggests that Cdk5 has comparable but also distinct functions in adult neurogenesis. Here we summarize accumulating evidence on the role of Cdk5 in regulation of the cell cycle, migration, survival, maturation and neuronal integration. We specifically highlight the many similarities and few tantalizing differences in the roles of Cdk5 in the embryonic and adult brain. We discuss the signaling pathways that might contribute to Cdk5 action in regulating embryonic and adult neurogenesis, highlighting future research directions that will help to clarify the mechanisms underlying lifelong neurogenesis in the mammalian brain.
细胞周期蛋白依赖性激酶5（Cdk5）与胚胎发育过程中产生的神经元的迁移、成熟和存活有关。新证据表明，Cdk5在成体神经发生中具有类似但也不同的功能。在这里，我们总结了关于Cdk5在细胞周期调控、迁移、存活、成熟和神经元整合中的作用的越来越多的证据。我们特别强调了Cdk5在胚胎和成年大脑中的作用的许多相似之处和一些诱人的差异。我们讨论了可能有助于Cdk5在调节胚胎和成体神经发生中发挥作用的信号通路，突出了未来的研究方向，这些方向将有助于阐明哺乳动物大脑中终身神经发生的潜在机制。
