Analytical Research and Development, US Pharmacopeial Convention, Rockville, MD 20852-1790, USA.
J Pharm Biomed Anal. 2010 Feb 5;51(3):507-11. doi: 10.1016/j.jpba.2009.08.025. Epub 2009 Aug 29.
This paper describes a capillary gas chromatographic method with flame ionization detection for the identification/quantification of ethylene glycol (EG) and diethylene glycol (DEG) in glycerin. The validation study shows that the proposed method is specific, sensitive, precise, and accurate. The linear range of the method was 0.013-0.031mg/mL for EG and 0.012-0.030mg/mL for DEG. Wider ranges may be achievable but were not investigated. The limit of detection of EG and DEG were determined as 0.0018% and 0.0036% (w/w) respectively, and at this concentration the signal-to-noise ratios for EG and DEG were approximately 3:1. The method was also used to determine EG and DEG in toothpaste. The results were compared to those obtained by thin-layer chromatography (TLC) and showed greater sensitivity and specificity.
本文描述了一种使用火焰离子化检测的毛细管气相色谱法，用于鉴定/定量甘油中的乙二醇（EG）和二乙二醇（DEG）。验证研究表明，该方法具有特异性、灵敏度、精密度和准确性。该方法的线性范围为 EG 为 0.013-0.031mg/mL，DEG 为 0.012-0.030mg/mL。可能可以实现更宽的范围，但未进行研究。EG 和 DEG 的检测限分别确定为 0.0018%和 0.0036%（w/w），在此浓度下，EG 和 DEG 的信噪比约为 3:1。该方法还用于测定牙膏中的 EG 和 DEG。结果与薄层色谱（TLC）法进行了比较，显示出更高的灵敏度和特异性。
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