Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore.
Epilepsy Res. 2009 Dec;87(2-3):107-19. doi: 10.1016/j.eplepsyres.2009.08.014. Epub 2009 Sep 25.
This study aims to (1) review the impact of epilepsy on the health-related quality of life (HRQoL) of Asian adult persons with epilepsy (PWE), and (2) identify the extent of stigma they experience and the associated factors. The electronic databases Medline, PsycINFO, ISI Web of Science, and the International Pharmaceutical Abstracts were searched using a combination of keywords to identify relevant journal articles published before October 2007, and supplemental manual searches of article bibliographies and the journal Neurology Asia were conducted. Thirty-six articles that met the predetermined inclusion criteria were selected and reviewed. The HRQoL of Asian adult PWE was lower than that of the general population. These PWE had difficulties in both physical and psychosocial functioning. Psychosocial factors appeared to have a more significant impact on PWE's HRQoL than physical factors. Stigma and negative attitudes towards marriage and employment of PWE was prevalent in many Asian countries, and the stigma's associated factors were multifaceted. Given the prevalent negative attitudes towards epilepsy, public education campaigns targeting misconceptions and associated factors may help reduce stigma and, together with psychosocial support, the HRQoL of Asian adult PWE can be improved.
（1）综述癫痫对亚洲成年癫痫患者（PWE）健康相关生活质量（HRQoL）的影响；（2）确定他们所经历的污名程度及其相关因素。使用关键词组合在电子数据库 Medline、PsycINFO、ISI Web of Science 和国际药学文摘中进行了检索，以查找 2007 年 10 月前发表的相关期刊文章，并对文章参考文献和期刊 Neurology Asia 进行了补充手动检索。选择并审查了符合预定纳入标准的 36 篇文章。亚洲成年 PWE 的 HRQoL 低于一般人群。这些 PWE 在身体和社会心理功能方面都存在困难。社会心理因素似乎对 PWE 的 HRQoL 产生比身体因素更显著的影响。在许多亚洲国家，普遍存在对 PWE 的污名化和对婚姻和就业的负面态度，污名化的相关因素是多方面的。鉴于对癫痫的普遍负面态度，针对误解和相关因素的公众教育运动可能有助于减少污名化，同时提供社会心理支持，可以改善亚洲成年 PWE 的 HRQoL。
