德国曾接触石棉的男性监测队列中的癌症死亡率。

Cancer mortality in a surveillance cohort of German males formerly exposed to asbestos.

机构信息

Center of Epidemiology, BGFA - Research Institute of Occupational Medicine of the German Social Accident Insurance, Institute of Ruhr University Bochum, Germany.

出版信息

Int J Hyg Environ Health. 2010 Jan;213(1):44-51. doi: 10.1016/j.ijheh.2009.09.001. Epub 2009 Sep 26.

DOI:10.1016/j.ijheh.2009.09.001

PMID:19783208

Abstract

The objective of this analysis was the estimation of the cancer risks of asbestos and asbestosis in a surveillance cohort of high-exposed German workers. A group of 576 asbestos workers was selected for high-resolution computer tomography of the chest in 1993-1997. A mortality follow-up was conducted through 2007. Standardised mortality ratios (SMRs) were calculated and Poisson regression was performed to assess mesothelioma risks. A high risk was observed for pleural mesothelioma (SMR 28.10, 95% CI 15.73-46.36) that decreased after cessation of exposure (RR 0.1; 95% CI 0.0-0.6 for > or =30 vs. <30 years after last exposure). Asbestosis was a significant risk factor for mesothelioma (RR 6.0, 95% CI 2.4-14.7). Mesothelioma mortality was still in excess in former asbestos workers although decreasing after cessation of exposure. Fibrosis was associated with subsequent malignancy.

摘要

本分析旨在估算接触史明确的德国高暴露工人中石棉和石棉沉着病的癌症风险。1993-1997 年间，选择了一组 576 名石棉工人进行胸部高分辨率计算机断层扫描。通过 2007 年的随访来进行死亡率的统计。计算了标准化死亡率比（SMR）并进行泊松回归来评估间皮瘤风险。观察到胸膜间皮瘤的风险很高（SMR 28.10，95%CI 15.73-46.36），接触停止后风险降低（RR 0.1；95%CI 0.0-0.6，对于最后接触后 >或=30 年与 <30 年）。石棉沉着病是间皮瘤的一个显著危险因素（RR 6.0，95%CI 2.4-14.7）。尽管接触停止后风险降低，但前石棉工人的间皮瘤死亡率仍偏高。纤维化与随后的恶性肿瘤有关。