采用液相色谱-串联质谱法测定脐带中苯丙胺和甲基苯丙胺。
Determination of amphetamine and methamphetamine in umbilical cord using liquid chromatography-tandem mass spectrometry.
作者信息
Jones Joseph, Rios Rosemarie, Jones Mary, Lewis Douglas, Plate Charles
机构信息
United States Drug Testing Laboratories, Des Plaines, IL 60018, United States.
出版信息
J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Nov 1;877(29):3701-6. doi: 10.1016/j.jchromb.2009.09.021. Epub 2009 Sep 19.
Abstract
The use of meconium as a drug-screening matrix for newborns has been the gold standard of care for the past two decades. A recent study using matched pairs of meconium and umbilical cord demonstrated a high degree of agreement. The use of liquid chromatography-tandem mass spectrometry as a means to confirm amphetamines presumptive positive umbilical cord specimens for amphetamine and methamphetamine is described here for the first time. The limit of detection for both compounds was 0.2 ng/g. The limit of quantitation for both compounds was 0.6 ng/g. The assay was linear for both compounds up to 100 ng/g.
摘要
在过去二十年里，使用胎粪作为新生儿药物筛查基质一直是护理的金标准。最近一项使用配对胎粪和脐带样本的研究显示出高度一致性。本文首次描述了使用液相色谱 - 串联质谱法来确认脐带样本中苯丙胺和甲基苯丙胺疑似阳性的情况。两种化合物的检测限均为0.2 ng/g。两种化合物的定量限均为0.6 ng/g。该检测方法对两种化合物在高达100 ng/g的范围内呈线性。
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