利用脐带组织来识别产前乙醇暴露以及与其他常见滥用物质的共同暴露情况。
Using umbilical cord tissue to identify prenatal ethanol exposure and co-exposure to other commonly misused substances.
作者信息
Jones Joseph, Coy Donna, Gidron Dominique, Hariharan Shanthi, Jones Mary, Patel Niranjan, Racines Amy, Toma Sarah, Brown Guida
机构信息
United States Drug Testing Laboratories, Des Plaines, IL, USA.
Guided by Guida, Kenosha, WI, USA.
出版信息
J Perinatol. 2025 Apr;45(4):454-457. doi: 10.1038/s41372-024-02075-2. Epub 2024 Jul 28.
OBJECTIVE
Substance misuse during pregnancy can result in a variety of poor pregnancy outcomes. Objective data reporting the prevalence of neonates born with ethanol metabolites (evidence of prenatal ethanol exposure) in their fluids or tissues are limited.
STUDY DESIGN
A secondary analysis of umbilical cord tissue specimens received for routine toxicological analysis was conducted. Prevalences of ethyl glucuronide (EtG), a long-term direct ethanol biomarker, were determined using a new laboratory tool, LDTD-MSMS. Additionally, other commonly misused substances were determined using routine procedures.
RESULTS
Of 12,995 specimens, 238 (1.8%) specimens contained EtG. Concentrations of EtG ranged from 5 ng/g to 6679 ng/g (median 47 ng/mg; IQR: 16 ng/g, 203 ng/g). Of those 238 EtG-positive specimens, nearly 58% (N = 138) contained additional substances or metabolites.
CONCLUSION
Self-report of substance use during pregnancy is under-reported. We have demonstrated co-exposure of substances with ethanol is higher than previous reports.
目的
孕期药物滥用可导致多种不良妊娠结局。关于在新生儿体液或组织中检测到乙醇代谢物（产前乙醇暴露证据）的新生儿患病率的客观数据有限。
研究设计
对接受常规毒理学分析的脐带组织标本进行二次分析。使用一种新的实验室工具LDTD-MSMS测定长期直接乙醇生物标志物葡萄糖醛酸乙酯（EtG）的患病率。此外，使用常规程序测定其他常见滥用物质。
结果
在12995份标本中，238份（1.8%）标本含有EtG。EtG浓度范围为5 ng/g至6679 ng/g（中位数47 ng/mg；四分位间距：16 ng/g，203 ng/g）。在这238份EtG阳性标本中，近58%（N = 138）含有其他物质或代谢物。
结论
孕期药物使用的自我报告存在漏报情况。我们已证明物质与乙醇的共同暴露高于先前报告。
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