N Paulescu National Institute of Diabetes, Nutrition and Metabolic Diseases, Bucharest, Romania.
Diabetes Res Clin Pract. 2009 Nov;86(2):146-51. doi: 10.1016/j.diabres.2009.08.012. Epub 2009 Sep 23.
To investigate the survival with diabetes in patients treated with insulin from diagnosis.
We analyzed 845 subjects, 55.9% males, registered at "I. Pavel" Bucharest Diabetes Centre, insulin-treated from diagnosis, aged <40 years and deceased between 1946 and 2005. We divided the subjects in two groups by age at diagnosis: group A <18 years and group B 18-39.99 years. We used 20 years time periods for year of death: 1946-1965, 1966-1985 and 1986-2005.
The mean age at diabetes onset was 30.36+/-8.04 years, disease duration at death 20.98+/-11.62 years and age at death 51.34+/-14.37 years. The mean increase in survival with diabetes was 19.3 years for group A and 15.9 years for group B. There was a significant decrease in infections in both groups. The increase in coronary heart diseases and stroke is evident only in group B.
We found no changes in age at onset, which combined with an increase in survival with diabetes lead to a significant increase in age at death over the six decades analyzed.
研究从确诊开始接受胰岛素治疗的糖尿病患者的生存情况。
我们分析了 845 名受试者的数据，其中 55.9%为男性，登记在布加勒斯特糖尿病中心“IPavel”，从确诊开始即接受胰岛素治疗，年龄<40 岁，于 1946 年至 2005 年间死亡。我们根据诊断时的年龄将受试者分为两组：A 组<18 岁，B 组 18-39.99 岁。我们使用 20 年的时间段来划分死亡年份：1946-1965 年、1966-1985 年和 1986-2005 年。
糖尿病发病的平均年龄为 30.36+/-8.04 岁，死亡时的病程为 20.98+/-11.62 年，死亡时的年龄为 51.34+/-14.37 岁。A 组糖尿病患者的平均生存时间延长了 19.3 年，B 组延长了 15.9 年。两组感染的发生率均显著下降。仅在 B 组中，冠心病和中风的发生率有所增加。
我们发现发病年龄没有变化，而糖尿病患者的生存时间延长，导致在这六十年间，死亡年龄显著增加。
