Tanaka Toyohito, Takahashi Osamu, Oishi Shinshi, Ogata Akio
Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health, Hyakunincho, Shinjuku-ku, Tokyo, Japan.
Toxicol Ind Health. 2009 Aug;25(7):489-97. doi: 10.1177/0748233709346756.
Piperonyl butoxide was given in the diet to provide levels of 0 (control), 0.02%, 0.06%, and 0.18% from 5 weeks of age of the F(0) generation to 12 weeks of age of the F(1) generation in mice. Select reproductive and neurobehavioral parameters were then measured. In exploratory behavior in the F(0) generation, vertical time of adult females increased significantly in a dose-related manner. In behavioral developmental parameters, cliff avoidance was delayed significantly in the high-dose group in male offspring, and this effect was significantly dose-related. In female offspring, surface righting was significantly delayed in the high-dose group, and this effect was significantly dose-related. In spontaneous behavior in the F(1) generation, females showed more activities in some variables in the high-dose group. Dose levels of piperonyl butoxide used in the present study produced several adverse effects in neurobehavioral parameters in mice.
在小鼠中，从F(0)代5周龄到F(1)代12周龄，在饮食中添加胡椒基丁醚，使其含量分别为0（对照）、0.02%、0.06%和0.18%。然后测量选定的生殖和神经行为参数。在F(0)代的探索行为中，成年雌性的垂直活动时间以剂量相关的方式显著增加。在行为发育参数方面，高剂量组雄性后代的悬崖回避显著延迟，且这种影响与剂量显著相关。在雌性后代中，高剂量组的表面翻正显著延迟，且这种影响与剂量显著相关。在F(1)代的自发行为中，高剂量组雌性在某些变量上表现出更多活动。本研究中使用的胡椒基丁醚剂量水平对小鼠的神经行为参数产生了多种不良影响。
