Clarkson J E, Young L, Ramsay C R, Bonner B C, Bonetti D
DHSRU, University of Dundee, MacKenzie Building, Kirsty Semple Way, Dundee, DD2 4BF UK.
J Dent Res. 2009 Oct;88(10):933-7. doi: 10.1177/0022034509345627.
Considerable resources are expended in dealing with dental disease easily prevented with better oral hygiene. The study hypothesis was that an evidence-based intervention, framed with psychological theory, would improve patients' oral hygiene behavior. The impact of trial methodology on trial outcomes was also explored by the conducting of two independent trials, one randomized by patient and one by dentist. The study included 87 dental practices and 778 patients (Patient RCT = 37 dentists/300 patients; Cluster RCT = 50 dentists/478 patients). Controlled for baseline differences, pooled results showed that patients who experienced the intervention had better behavioral (timing, duration, method), cognitive (confidence, planning), and clinical (plaque, gingival bleeding) outcomes. However, clinical outcomes were significantly better only in the Cluster RCT, suggesting that the impact of trial design on results needs to be further explored.
在应对通过更好的口腔卫生很容易预防的牙科疾病方面，投入了大量资源。研究假设是，基于循证的干预措施，结合心理学理论，将改善患者的口腔卫生行为。还通过进行两项独立试验来探讨试验方法对试验结果的影响，一项试验按患者随机分组，另一项按牙医随机分组。该研究包括87家牙科诊所和778名患者（患者随机对照试验 = 37名牙医/300名患者；整群随机对照试验 = 50名牙医/478名患者）。在控制基线差异后，汇总结果显示，接受干预的患者在行为（时间、持续时间、方法）、认知（信心、计划）和临床（牙菌斑、牙龈出血）方面有更好的结果。然而，仅在整群随机对照试验中临床结果显著更好，这表明试验设计对结果的影响需要进一步探索。
