Department of Clinical Chemistry and Informatics, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Japan.
J Pharmacol Sci. 2009 Oct;111(2):211-5. doi: 10.1254/jphs.09128sc. Epub 2009 Sep 26.
This study examined the effect of ozagrel, a thromboxane A(2) synthase inhibitor, on the accumulation of leucocytes and chemokine mRNA expression in lungs experimentally injured using oleic acid (OA). OA injection into guinea pigs rapidly increased thromboxane A(2) generation and subsequently increased total protein concentration and the numbers of macrophages and neutrophils in bronchoalveolar lavage fluid and increased monocyte chemoattractant protein-1 and interleukin-8 mRNA expression in the whole lung. Administration of ozagrel prevented these changes associated with OA injection. Ozagrel is a promising drug candidate for preventing acute lung injury.
本研究考察了血栓素 A2 合酶抑制剂奥扎格雷（ozagrel）对油酸（OA）致实验性肺损伤时白细胞积聚和趋化因子 mRNA 表达的影响。OA 注射到豚鼠体内可迅速增加血栓素 A2 的产生，随后增加支气管肺泡灌洗液中总蛋白浓度以及巨噬细胞和中性粒细胞的数量，并增加整个肺中单核细胞趋化蛋白-1 和白细胞介素-8 mRNA 的表达。奥扎格雷的给药可预防与 OA 注射相关的这些变化。奥扎格雷是预防急性肺损伤的一种很有前途的候选药物。
