Kotlyarov Stanislav
Department of Nursing, Ryazan State Medical University, 390026 Ryazan, Russia.
Pathophysiology. 2025 Jun 6;32(2):26. doi: 10.3390/pathophysiology32020026.
Lipids play important roles in maintaining pulmonary structure, performing physiological functions and controlling the immune status of the lung. There is increasing evidence that lipid metabolism and immune activity are closely linked and that dysfunction in lipid metabolism contributes to the development and progression of chronic respiratory diseases such as COPD and asthma. These diseases are characterized by metabolic and immune dysregulation, with lipid mediators playing a key role in both the development and resolution of inflammation. In this regard, lipid metabolic pathways are attracting increasing attention as promising targets for biomarker detection and therapeutic intervention.
脂质在维持肺部结构、执行生理功能以及控制肺部免疫状态方面发挥着重要作用。越来越多的证据表明，脂质代谢与免疫活性密切相关，脂质代谢功能障碍会导致慢性呼吸道疾病（如慢性阻塞性肺疾病和哮喘）的发生和发展。这些疾病的特征是代谢和免疫失调，脂质介质在炎症的发生和消退中均起关键作用。在这方面，脂质代谢途径作为生物标志物检测和治疗干预的有前景的靶点正受到越来越多的关注。
